LAMB1 downregulation suppresses glioma progression by inhibiting aerobic glycolysis through regulation of the NF-κB/HK2 axis

LAMB1 downregulation suppresses glioma progression by inhibiting aerobic glycolysis through regulation of the NF-κB/HK2 axis

Abstract Background Laminin subunit beta 1 (LAMB1) has regulatory functions on the proliferation, attachment, and migration of tumor cells, with increased levels linked to different cancers. Objective This study aims at investigating the effects and mechanisms of LAMB1 in glioma. Methods and materia...

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Bibliographic Details
Main Authors: Zhenxiang Zhao, Haiying Liu, Yingzi Liu, Junpeng Wen, Jiangwei Yuan
Format: Article
Language:English
Published: Springer 2025-02-01
Series:Discover Oncology
Subjects:
LAMB1
Glioma
Temozolomide
Resistance
Glycolysis
NF-κB
Online Access:https://doi.org/10.1007/s12672-025-01818-7
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