Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases
Sterile and infection-associated inflammatory diseases are becoming increasingly prevalent worldwide. Conventional drug therapies often entail significant drawbacks, such as the risk of drug overdose, the development of drug resistance in pathogens, and systemic adverse reactions, all of which can u...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Ultrasonics Sonochemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1350417725000495 |
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| author | Kai Zhang Tingting Wang Xingyong Huang Peng Wu Lufan Shen Yuanyuan Yang Wenyu Wan Siyu Sun Zhan Zhang |
| author_facet | Kai Zhang Tingting Wang Xingyong Huang Peng Wu Lufan Shen Yuanyuan Yang Wenyu Wan Siyu Sun Zhan Zhang |
| author_sort | Kai Zhang |
| collection | DOAJ |
| description | Sterile and infection-associated inflammatory diseases are becoming increasingly prevalent worldwide. Conventional drug therapies often entail significant drawbacks, such as the risk of drug overdose, the development of drug resistance in pathogens, and systemic adverse reactions, all of which can undermine the effectiveness of treatments for these conditions. Nanomaterials (NMs) have emerged as a promising tool in the treatment of inflammatory diseases due to their precise targeting capabilities, tunable characteristics, and responsiveness to external stimuli. Ultrasound (US), a non-invasive and effective treatment method, has been explored in combination with NMs to achieve enhanced therapeutic outcomes. This review provides a comprehensive overview of the recent advances in the use of US-mediated NMs for treating inflammatory diseases. A comprehensive introduction to the application and classification of US was first presented, emphasizing the advantages of US-mediated NMs and the mechanisms through which US and NMs interact to enhance anti-inflammatory therapy. Subsequently, specific applications of US-mediated NMs in sterile and infection-associated inflammation were summarized. Finally, the challenges and prospects of US-mediated NMs in clinical translation were discussed, along with an outline of future research directions. This review aims to provide insights to guide the development and improvement of US-mediated NMs for more effective therapeutic interventions in inflammatory diseases. |
| format | Article |
| id | doaj-art-6d48c4e2691c4e279b9069f15ada5578 |
| institution | DOAJ |
| issn | 1350-4177 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ultrasonics Sonochemistry |
| spelling | doaj-art-6d48c4e2691c4e279b9069f15ada55782025-08-20T02:43:19ZengElsevierUltrasonics Sonochemistry1350-41772025-03-0111410727010.1016/j.ultsonch.2025.107270Ultrasound-mediated nanomaterials for the treatment of inflammatory diseasesKai Zhang0Tingting Wang1Xingyong Huang2Peng Wu3Lufan Shen4Yuanyuan Yang5Wenyu Wan6Siyu Sun7Zhan Zhang8Department of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, PR China; Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, PR ChinaDepartment of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, PR ChinaDepartment of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, PR ChinaDepartment of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, PR ChinaDepartment of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, PR ChinaDepartment of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, PR ChinaKey Laboratory of Immunodermatology, Ministry of Education, Department of Dermatology, The First Hospital of China Medical University, PR China; Key Laboratory of Immunodermatology, National Health Commission of the People’s Republic of China, The First Hospital of China Medical University, PR China; National and Local Joint Engineering Research Center of Immunodermatological Theranostics, The First Hospital of China Medical University, PR China; Corresponding authors at: Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, PR China (Z. Zhang).Department of Gastroenterology, Endoscopic Center, Shengjing Hospital of China Medical University, PR China; Engineering Research Center of Ministry of Education for Minimally Invasive Gastrointestinal Endoscopic Techniques, Shengjing Hospital of China Medical University, PR China; Corresponding authors at: Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, PR China (Z. Zhang).Department of Oncology, Shengjing Hospital of China Medical University, PR China; Cancer Stem Cell and Translational Medicine Laboratory, Shengjing Hospital of China Medical University, Shenyang, PR China; Corresponding authors at: Department of Oncology, Shengjing Hospital of China Medical University, Shenyang, PR China (Z. Zhang).Sterile and infection-associated inflammatory diseases are becoming increasingly prevalent worldwide. Conventional drug therapies often entail significant drawbacks, such as the risk of drug overdose, the development of drug resistance in pathogens, and systemic adverse reactions, all of which can undermine the effectiveness of treatments for these conditions. Nanomaterials (NMs) have emerged as a promising tool in the treatment of inflammatory diseases due to their precise targeting capabilities, tunable characteristics, and responsiveness to external stimuli. Ultrasound (US), a non-invasive and effective treatment method, has been explored in combination with NMs to achieve enhanced therapeutic outcomes. This review provides a comprehensive overview of the recent advances in the use of US-mediated NMs for treating inflammatory diseases. A comprehensive introduction to the application and classification of US was first presented, emphasizing the advantages of US-mediated NMs and the mechanisms through which US and NMs interact to enhance anti-inflammatory therapy. Subsequently, specific applications of US-mediated NMs in sterile and infection-associated inflammation were summarized. Finally, the challenges and prospects of US-mediated NMs in clinical translation were discussed, along with an outline of future research directions. This review aims to provide insights to guide the development and improvement of US-mediated NMs for more effective therapeutic interventions in inflammatory diseases.http://www.sciencedirect.com/science/article/pii/S1350417725000495UltrasoundInflammatory diseasesNanomaterialsSterile inflammationInfection |
| spellingShingle | Kai Zhang Tingting Wang Xingyong Huang Peng Wu Lufan Shen Yuanyuan Yang Wenyu Wan Siyu Sun Zhan Zhang Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases Ultrasonics Sonochemistry Ultrasound Inflammatory diseases Nanomaterials Sterile inflammation Infection |
| title | Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases |
| title_full | Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases |
| title_fullStr | Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases |
| title_full_unstemmed | Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases |
| title_short | Ultrasound-mediated nanomaterials for the treatment of inflammatory diseases |
| title_sort | ultrasound mediated nanomaterials for the treatment of inflammatory diseases |
| topic | Ultrasound Inflammatory diseases Nanomaterials Sterile inflammation Infection |
| url | http://www.sciencedirect.com/science/article/pii/S1350417725000495 |
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