Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants.

Sequential Immunization with gp140 Boosts Immune Responses Primed by Modified Vaccinia Ankara or DNA in HIV-Uninfected South African Participants.

<h4>Background</h4>The safety and immunogenicity of SAAVI DNA-C2 (4 mg IM), SAAVI MVA-C (2.9 x 109 pfu IM) and Novartis V2-deleted subtype C gp140 (100 mcg) with MF59 adjuvant in various vaccination regimens was evaluated in HIV-uninfected adults in South Africa.<h4>Methods</h4&...

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Main Authors: Gavin Churchyard, Koleka Mlisana, Shelly Karuna, Anna-Lise Williamson, Carolyn Williamson, Lynn Morris, Georgia D Tomaras, Stephen C De Rosa, Peter B Gilbert, Niya Gu, Chenchen Yu, Nonhlanhla N Mkhize, Tandile Hermanus, Mary Allen, Michael Pensiero, Susan W Barnett, Glenda Gray, Linda-Gail Bekker, David C Montefiori, James Kublin, Lawrence Corey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0161753&type=printable
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