HEV study protocol : design of a cluster-randomised, blinded trial to assess the safety, immunogenicity and effectiveness of the hepatitis E vaccine HEV 239 (Hecolin) in women of childbearing age in rural Bangladesh

HEV study protocol : design of a cluster-randomised, blinded trial to assess the safety, immunogenicity and effectiveness of the hepatitis E vaccine HEV 239 (Hecolin) in women of childbearing age in rural Bangladesh

Introduction Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis in the developing world and is a public health problem, in particular among pregnant women, where it may lead to severe or fatal complications. A recombinant HEV vaccine, 239 (Hecolin; Xiamen Innovax Biotech, Xiamen, Ch...

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Main Authors: Anisur Rahman, K Zaman, Susanne Dudman, Kathrine Stene-Johansen, Firdausi Qadri, Md Yunus, Synne Sandbu, Emily S Gurley, Joakim Overbo, Cathinka Halle Julin, Jennifer Lynn Dembinski, Quamrun Nahar, Taufiqur R Bhuiyan, Mustafizur Rahman, Warda Haque, Jahangir Khan, Asma Aziz, Mahbuba Khanam, Peter Kim Streatfield, John D Clemens
Format: Article
Language:English
Published: BMJ Publishing Group 2020-01-01
Series:BMJ Open
Online Access:https://bmjopen.bmj.com/content/10/1/e033702.full
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