Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis
The purpose of this study was to investigate comparison between oral zinc sulfate and meglumine antimoniate in the treatment of cutaneous leishmaniasis (CL). So 100 patients with CL were included and randomly divided into two groups. The first group was treated with oral zinc sulfate (10 mg/kg/day d...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2011/269515 |
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| author | Mohamad Javad Yazdanpanah Mahnaz Banihashemi Fakhrozaman Pezeshkpoor Mohammad Khajedaluee Sororozaman Famili Iman Tavakoli Rodi Hadis Yousefzadeh |
| author_facet | Mohamad Javad Yazdanpanah Mahnaz Banihashemi Fakhrozaman Pezeshkpoor Mohammad Khajedaluee Sororozaman Famili Iman Tavakoli Rodi Hadis Yousefzadeh |
| author_sort | Mohamad Javad Yazdanpanah |
| collection | DOAJ |
| description | The purpose of this study was to investigate comparison between oral zinc sulfate and meglumine antimoniate in the treatment of cutaneous leishmaniasis (CL). So 100 patients with CL were included and randomly divided into two groups. The first group was treated with oral zinc sulfate (10 mg/kg/day during 45 days period), and the second group was treated with systemic meglumine antimoniate (20 mg/kg/day intramuscularly for 20 days). Acceptable cure after completing 45 days of followup occurred in 30.2% of lesions in first group, while this was 35.5% for the second group. There is not any significant difference between the two treatment groups (𝑃=0.42). Serious side effects resulting in treatment discounting occurred in only meglumine antimoniate group. Although cure rate of systemic meglumine antimoniate group was better the treatment with zinc sulfate is much easier, cheaper, more convenient in consumption, safer, and nearly close cure percentage to systemic meglumine antimoniate injections without serious side effect. |
| format | Article |
| id | doaj-art-6d3616c4db344367a5ee833fefe25856 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-6d3616c4db344367a5ee833fefe258562025-02-03T01:24:00ZengWileyDermatology Research and Practice1687-61051687-61132011-01-01201110.1155/2011/269515269515Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous LeishmaniasisMohamad Javad Yazdanpanah0Mahnaz Banihashemi1Fakhrozaman Pezeshkpoor2Mohammad Khajedaluee3Sororozaman Famili4Iman Tavakoli Rodi5Hadis Yousefzadeh6Research Center for Skin Disease and Cutaneous Leishmaniasis, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, IranResearch Center for Skin Disease and Cutaneous Leishmaniasis, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, IranResearch Center for Skin Disease and Cutaneous Leishmaniasis, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, IranDepartment of Social Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, IranResearch Center for Skin Disease and Cutaneous Leishmaniasis, Ghaem Hospital, School of Medicine, Mashhad University of Medical Sciences (MUMS), Mashhad, IranMashhad University of Medical Sciences (MUMS), Mashhad, IranYoung Researcher's Club, Islamic Azad university, Mashhad branch, IranThe purpose of this study was to investigate comparison between oral zinc sulfate and meglumine antimoniate in the treatment of cutaneous leishmaniasis (CL). So 100 patients with CL were included and randomly divided into two groups. The first group was treated with oral zinc sulfate (10 mg/kg/day during 45 days period), and the second group was treated with systemic meglumine antimoniate (20 mg/kg/day intramuscularly for 20 days). Acceptable cure after completing 45 days of followup occurred in 30.2% of lesions in first group, while this was 35.5% for the second group. There is not any significant difference between the two treatment groups (𝑃=0.42). Serious side effects resulting in treatment discounting occurred in only meglumine antimoniate group. Although cure rate of systemic meglumine antimoniate group was better the treatment with zinc sulfate is much easier, cheaper, more convenient in consumption, safer, and nearly close cure percentage to systemic meglumine antimoniate injections without serious side effect.http://dx.doi.org/10.1155/2011/269515 |
| spellingShingle | Mohamad Javad Yazdanpanah Mahnaz Banihashemi Fakhrozaman Pezeshkpoor Mohammad Khajedaluee Sororozaman Famili Iman Tavakoli Rodi Hadis Yousefzadeh Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis Dermatology Research and Practice |
| title | Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis |
| title_full | Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis |
| title_fullStr | Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis |
| title_full_unstemmed | Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis |
| title_short | Comparison of Oral Zinc Sulfate with Systemic Meglumine Antimoniate in the Treatment of Cutaneous Leishmaniasis |
| title_sort | comparison of oral zinc sulfate with systemic meglumine antimoniate in the treatment of cutaneous leishmaniasis |
| url | http://dx.doi.org/10.1155/2011/269515 |
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