Neoadjuvant Chemotherapy Versus Adjuvant Chemotherapy for Very Low-Lying Clinical T3 Rectal Cancer: The NAIR Phase 2/3 Randomized Clinical Trial

Neoadjuvant Chemotherapy Versus Adjuvant Chemotherapy for Very Low-Lying Clinical T3 Rectal Cancer: The NAIR Phase 2/3 Randomized Clinical Trial

Objective:. To determine whether neoadjuvant chemotherapy (NAC) followed by total mesorectal excision (TME) and adjuvant chemotherapy (AC) is superior to TME followed by AC for very low-lying clinical (c) T3 rectal cancer. Background:. Preoperative radiation is widely used for preoperative treatment...

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Main Authors: Yuichiro Tsukada, MD, PhD, Norio Saito, MD, PhD, Yuji Nishizawa, MD, PhD, Riki Ohno, MD, PhD, Fumihiko Fujita, MD, PhD, Keiji Koda, MD, PhD, Masayuki Ohue, MD, PhD, Eiji Shinto, MD, PhD, Akihiko Murata, MD, PhD, Yoshikazu Koide, MD, PhD, Koji Ikeda, MD, PhD, Hideaki Bando, MD, PhD, Motoko Suzuki, Toshihiro Misumi, PhD, Takayuki Yoshino, MD, PhD, Masaaki Ito, MD, PhD
Format: Article
Language:English
Published: Wolters Kluwer Health 2025-06-01
Series:Annals of Surgery Open
Online Access:http://journals.lww.com/10.1097/AS9.0000000000000579
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