Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers?
Background. The prognosis of gastric cancer patients still remains poor. The aim of this study was investigating the prognostic value of several clinical/pathological/molecular features in a consecutive series of gastric cancers. Methods. 150 R0 gastrectomies plus 77 gastric cancer patients evaluate...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/196541 |
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| author | Laura Lorenzon Paolo Mercantini Mario Ferri Marco La Torre Alessandra Sparagna Genoveffa Balducci Giulia Tarantino Adriana Romiti Emanuela Pilozzi Vincenzo Ziparo |
| author_facet | Laura Lorenzon Paolo Mercantini Mario Ferri Marco La Torre Alessandra Sparagna Genoveffa Balducci Giulia Tarantino Adriana Romiti Emanuela Pilozzi Vincenzo Ziparo |
| author_sort | Laura Lorenzon |
| collection | DOAJ |
| description | Background. The prognosis of gastric cancer patients still remains poor. The aim of this study was investigating the prognostic value of several clinical/pathological/molecular features in a consecutive series of gastric cancers. Methods. 150 R0 gastrectomies plus 77 gastric cancer patients evaluated for the HER2 overexpression were selected. Survival was calculated and patients stratified according to the stage, the T-stage, the LNRs, the LNH, and the HER2 scoring system. ROC curves were calculated in order to compare the performance of the LRN and LNH systems. Results. Prognosis correlated with the stage and with the T-stage. We documented a statistical correlation between the LNRs and the survival. Conversely, a LNH > 15 did not correlate with the outcomes. The ROC curves documented a significant performance of the LRN system, whereas a statistical correlation was documented for the LNH exclusively with the endpoint of disease-free survival. We documented a trend of worse prognosis for patients with an HER2 overexpression, even though it was not of statistical value. Conclusion. The LNR and the evaluation of the HER2 overexpression might be useful since they correlate with survival, might identify patients with a higher risk of recurrence, and might select patients for a tailored medical treatment. |
| format | Article |
| id | doaj-art-6d2dd48b1e2c47998bb6b4fd2d440f00 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-6d2dd48b1e2c47998bb6b4fd2d440f002025-08-20T03:33:51ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/196541196541Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers?Laura Lorenzon0Paolo Mercantini1Mario Ferri2Marco La Torre3Alessandra Sparagna4Genoveffa Balducci5Giulia Tarantino6Adriana Romiti7Emanuela Pilozzi8Vincenzo Ziparo9Surgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalySurgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalySurgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalySurgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalySurgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalySurgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalySurgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalyDepartment of Clinical and Molecular Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalyDepartment of Clinical and Molecular Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalySurgical and Medical Department of Translational Medicine, Sant’Andrea Hospital, Faculty of Medicine and Psychology, University of Rome “La Sapienza”, Via di Grottarossa 1035-39, 00189 Rome, ItalyBackground. The prognosis of gastric cancer patients still remains poor. The aim of this study was investigating the prognostic value of several clinical/pathological/molecular features in a consecutive series of gastric cancers. Methods. 150 R0 gastrectomies plus 77 gastric cancer patients evaluated for the HER2 overexpression were selected. Survival was calculated and patients stratified according to the stage, the T-stage, the LNRs, the LNH, and the HER2 scoring system. ROC curves were calculated in order to compare the performance of the LRN and LNH systems. Results. Prognosis correlated with the stage and with the T-stage. We documented a statistical correlation between the LNRs and the survival. Conversely, a LNH > 15 did not correlate with the outcomes. The ROC curves documented a significant performance of the LRN system, whereas a statistical correlation was documented for the LNH exclusively with the endpoint of disease-free survival. We documented a trend of worse prognosis for patients with an HER2 overexpression, even though it was not of statistical value. Conclusion. The LNR and the evaluation of the HER2 overexpression might be useful since they correlate with survival, might identify patients with a higher risk of recurrence, and might select patients for a tailored medical treatment.http://dx.doi.org/10.1155/2013/196541 |
| spellingShingle | Laura Lorenzon Paolo Mercantini Mario Ferri Marco La Torre Alessandra Sparagna Genoveffa Balducci Giulia Tarantino Adriana Romiti Emanuela Pilozzi Vincenzo Ziparo Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers? The Scientific World Journal |
| title | Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers? |
| title_full | Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers? |
| title_fullStr | Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers? |
| title_full_unstemmed | Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers? |
| title_short | Profiling the Prognosis of Gastric Cancer Patients: Is It Worth Correlating the Survival with the Clinical/Pathological and Molecular Features of Gastric Cancers? |
| title_sort | profiling the prognosis of gastric cancer patients is it worth correlating the survival with the clinical pathological and molecular features of gastric cancers |
| url | http://dx.doi.org/10.1155/2013/196541 |
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