Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyria
Acute intermittent porphyria (AIP), one of the most severe types of acute hepatic porphyria, is an autosomal dominant inherited disorder of heme biosynthesis. We present a case of a 16-year-old girl who presented with severe abdominal pain, subjected to a laparotomy and later developed seizures and...
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| Language: | English |
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Pakistan Medical Association
2024-10-01
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| Series: | Journal of the Pakistan Medical Association |
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| Online Access: | https://jpma.org.pk/index.php/public_html/article/view/10209 |
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| author | Tehreem Farah Hania Batool Nasir Ashraf Fatima Qayyum Abbasi Aisha Nasir |
| author_facet | Tehreem Farah Hania Batool Nasir Ashraf Fatima Qayyum Abbasi Aisha Nasir |
| author_sort | Tehreem Farah |
| collection | DOAJ |
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Acute intermittent porphyria (AIP), one of the most severe types of acute hepatic porphyria, is an autosomal dominant inherited disorder of heme biosynthesis. We present a case of a 16-year-old girl who presented with severe abdominal pain, subjected to a laparotomy and later developed seizures and other neurological manifestations. Initial investigations showed hyponatraemia. Magnetic Resonance Imaging of brain showed cerebritis. She underwent several investigations including an ultrasound of abdomen, a computed tomography scan of abdomen and pelvis, cerebrospinal fluid routine examination and culture, and autoimmune investigation which were found to be normal. HM urine porphobilinogen levels were found to be raised. The diagnosis was made based on investigation and clinical symptoms. AIP should be suspected when a patient presents with chronic abdominal pain and neurological symptoms.
Keywords: Acute Intermittent Porphyria, false laparotomy, appendicitis, acute abdomen, hyponatremia, tonic-clonic seizures.
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| format | Article |
| id | doaj-art-6d2bb12b6c1543bc989b5521c22a1bf2 |
| institution | DOAJ |
| issn | 0030-9982 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Pakistan Medical Association |
| record_format | Article |
| series | Journal of the Pakistan Medical Association |
| spelling | doaj-art-6d2bb12b6c1543bc989b5521c22a1bf22025-08-20T02:40:43ZengPakistan Medical AssociationJournal of the Pakistan Medical Association0030-99822024-10-01741110.47391/JPMA.10209Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyriaTehreem Farah0Hania Batool1Nasir Ashraf2Fatima Qayyum Abbasi3Aisha Nasir4Department of Obstetrics and Gynaecology, Pakistan Institute of Medical Sciences, Islamabad, PakistanDepartment of Obstetrics and Gynaecology, Pakistan Institute of Medical Sciences, Islamabad, PakistanDepartment of General Medicine, Pakistan Institute of Medical Sciences, Islamabad, PakistanFinal Year MBBS Student, Federal Medical College, Islamabad, PakistanFinal Year MBBS Student, Dera Ghazi Khan Medical College, Dera Ghazi Khan, Pakistan Acute intermittent porphyria (AIP), one of the most severe types of acute hepatic porphyria, is an autosomal dominant inherited disorder of heme biosynthesis. We present a case of a 16-year-old girl who presented with severe abdominal pain, subjected to a laparotomy and later developed seizures and other neurological manifestations. Initial investigations showed hyponatraemia. Magnetic Resonance Imaging of brain showed cerebritis. She underwent several investigations including an ultrasound of abdomen, a computed tomography scan of abdomen and pelvis, cerebrospinal fluid routine examination and culture, and autoimmune investigation which were found to be normal. HM urine porphobilinogen levels were found to be raised. The diagnosis was made based on investigation and clinical symptoms. AIP should be suspected when a patient presents with chronic abdominal pain and neurological symptoms. Keywords: Acute Intermittent Porphyria, false laparotomy, appendicitis, acute abdomen, hyponatremia, tonic-clonic seizures. https://jpma.org.pk/index.php/public_html/article/view/10209Acute Intermittent Porphyriafalse laparotomyappendicitisacute abdomenhyponatremiatonic-clonic seizures |
| spellingShingle | Tehreem Farah Hania Batool Nasir Ashraf Fatima Qayyum Abbasi Aisha Nasir Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyria Journal of the Pakistan Medical Association Acute Intermittent Porphyria false laparotomy appendicitis acute abdomen hyponatremia tonic-clonic seizures |
| title | Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyria |
| title_full | Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyria |
| title_fullStr | Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyria |
| title_full_unstemmed | Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyria |
| title_short | Worsening abdominal pain leading to false laparotomy: a case of acute intermittent porphyria |
| title_sort | worsening abdominal pain leading to false laparotomy a case of acute intermittent porphyria |
| topic | Acute Intermittent Porphyria false laparotomy appendicitis acute abdomen hyponatremia tonic-clonic seizures |
| url | https://jpma.org.pk/index.php/public_html/article/view/10209 |
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