Partial mitochondrial involvement in the antiproliferative and immunostimulatory effects of PT-112
PT-112 is a novel small molecule exhibiting promising clinical activity in patients with solid tumors. PT-112 kills malignant cells by inhibiting ribosome biogenesis while promoting the emission of immunostimulatory signals. Accordingly, PT-112 is an authentic immunogenic cell death (ICD) inducer an...
Saved in:
| Main Authors: | Ruth Soler-Agesta, Manuel Beltrán-Visiedo, Ai Sato, Takahiro Yamazaki, Emma Guilbaud, Christina Y. Yim, Maria T. Congenie, Tyler D. Ames, Alberto Anel, Lorenzo Galluzzi |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/2162402X.2025.2507245 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
The neuroimmune nexus: unraveling the role of the mtDNA-cGAS-STING signal pathway in Alzheimer’s disease
by: Shuiyue Quan, et al.
Published: (2025-03-01) -
A mitochondrial checkpoint to adaptive anticancer immunity
by: Oliver Kepp, et al.
Published: (2023-12-01) -
Pulmonary mitochondrial DNA release and activation of the cGAS-STING pathway in Lethal Stx12 knockout mice
by: Dan-Hua Liu, et al.
Published: (2025-04-01) -
Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis
by: Xiaoli Fan, et al.
Published: (2025-03-01) -
Flow-cytometry reveals mitochondrial DNA accumulation in Saccharomyces cerevisiae cells during cell cycle arrest
by: Elena Yu Potapenko, et al.
Published: (2024-12-01)