Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain
Background: Childhood obesity is a major public health concern, being linked to an increased risk of metabolic disorders and cardiovascular disease. Even in childhood, obesity is associated with systemic low-grade inflammation, which is a critical factor in the development of atherosclerosis and a p...
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MDPI AG
2025-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/12/1/89 |
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| author | Beatriz Fernández-Vallejo Francisco Jiménez Monteagudo Lourdes Romero Maria Isabel López Aznárez María del Carmen Romero Cobas Laura Pérez-Martínez |
| author_facet | Beatriz Fernández-Vallejo Francisco Jiménez Monteagudo Lourdes Romero Maria Isabel López Aznárez María del Carmen Romero Cobas Laura Pérez-Martínez |
| author_sort | Beatriz Fernández-Vallejo |
| collection | DOAJ |
| description | Background: Childhood obesity is a major public health concern, being linked to an increased risk of metabolic disorders and cardiovascular disease. Even in childhood, obesity is associated with systemic low-grade inflammation, which is a critical factor in the development of atherosclerosis and a predictor of cardiovascular morbidity and mortality. Objectives: To describe the prevalence of obesity and examine the relationship between IL-6, TNF-α, adiponectin, leptin, the leptin/adiponectin (L/A) ratio, and Klotho levels with BMI in children. Methods: This cross-sectional study included children aged 10–14 years from La Rioja, Spain. Participants were selected based on BMI criteria for overweight (85th–95th percentiles) and obesity (>95th percentile). Socio-demographic and anthropometric data and blood samples were collected and analyzed for IL-6, TNF-α, adiponectin, leptin, and Klotho. Results: A total of 340 participants were included, with 276 (81.2%) classified as normal weight and 64 (18.8%) as overweight or obese. Mean age was similar between groups (<i>p</i> = 0.40). Obesity was more prevalent in males (59.4%, <i>p</i> = 0.048). Obese participants had higher mean birth weight (<i>p</i> = 0.003), current height (<i>p</i> = 0.04), BMI (<i>p</i> < 0.0001), and abdominal circumference (<i>p</i> < 0.0001). BMI correlated positively with leptin (r = 0.54, <i>p</i> = 0.0008) and the L/A ratio (r = 0.40, <i>p</i> = 0.025), showing sex-specific differences. Conclusions: This study underscores leptin and the L/A ratio as potential biomarkers of metabolic dysregulation in childhood obesity, particularly in females. Longitudinal studies are needed to confirm these findings and assess the clinical utility of these biomarkers in pediatric obesity management. |
| format | Article |
| id | doaj-art-6d143ab76e7746f9b41f87adf043614f |
| institution | Kabale University |
| issn | 2227-9067 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Children |
| spelling | doaj-art-6d143ab76e7746f9b41f87adf043614f2025-01-24T13:27:15ZengMDPI AGChildren2227-90672025-01-011218910.3390/children12010089Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, SpainBeatriz Fernández-Vallejo0Francisco Jiménez Monteagudo1Lourdes Romero2Maria Isabel López Aznárez3María del Carmen Romero Cobas4Laura Pérez-Martínez5Servicio de Pediatría, Hospital Universitario San Pedro, 26006 Logroño, SpainPediatría de Atención Primaria, Centro de Salud Espartero, 26006 Logroño, SpainCentro de Investigación Biomédica de La Rioja (CIBIR), 26006 Logroño, SpainPediatría de Atención Primaria, Centro de Salud Guindalera, 26006 Logroño, SpainMedicina Familiar y Comunitaria, Centro de Salud Gonzalo de Berceo, 26006 Logroño, SpainCentro de Investigación Biomédica de La Rioja (CIBIR), 26006 Logroño, SpainBackground: Childhood obesity is a major public health concern, being linked to an increased risk of metabolic disorders and cardiovascular disease. Even in childhood, obesity is associated with systemic low-grade inflammation, which is a critical factor in the development of atherosclerosis and a predictor of cardiovascular morbidity and mortality. Objectives: To describe the prevalence of obesity and examine the relationship between IL-6, TNF-α, adiponectin, leptin, the leptin/adiponectin (L/A) ratio, and Klotho levels with BMI in children. Methods: This cross-sectional study included children aged 10–14 years from La Rioja, Spain. Participants were selected based on BMI criteria for overweight (85th–95th percentiles) and obesity (>95th percentile). Socio-demographic and anthropometric data and blood samples were collected and analyzed for IL-6, TNF-α, adiponectin, leptin, and Klotho. Results: A total of 340 participants were included, with 276 (81.2%) classified as normal weight and 64 (18.8%) as overweight or obese. Mean age was similar between groups (<i>p</i> = 0.40). Obesity was more prevalent in males (59.4%, <i>p</i> = 0.048). Obese participants had higher mean birth weight (<i>p</i> = 0.003), current height (<i>p</i> = 0.04), BMI (<i>p</i> < 0.0001), and abdominal circumference (<i>p</i> < 0.0001). BMI correlated positively with leptin (r = 0.54, <i>p</i> = 0.0008) and the L/A ratio (r = 0.40, <i>p</i> = 0.025), showing sex-specific differences. Conclusions: This study underscores leptin and the L/A ratio as potential biomarkers of metabolic dysregulation in childhood obesity, particularly in females. Longitudinal studies are needed to confirm these findings and assess the clinical utility of these biomarkers in pediatric obesity management.https://www.mdpi.com/2227-9067/12/1/89adipocytokineschildrenleptinleptin/adiponectin ratioobesityoverweight |
| spellingShingle | Beatriz Fernández-Vallejo Francisco Jiménez Monteagudo Lourdes Romero Maria Isabel López Aznárez María del Carmen Romero Cobas Laura Pérez-Martínez Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain Children adipocytokines children leptin leptin/adiponectin ratio obesity overweight |
| title | Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain |
| title_full | Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain |
| title_fullStr | Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain |
| title_full_unstemmed | Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain |
| title_short | Cross-Sectional Analysis of IL-6, TNF-α, Adiponectin, Leptin, and Klotho Serum Levels in Relation to BMI Among Overweight and Obese Children Aged 10–14 in La Rioja, Spain |
| title_sort | cross sectional analysis of il 6 tnf α adiponectin leptin and klotho serum levels in relation to bmi among overweight and obese children aged 10 14 in la rioja spain |
| topic | adipocytokines children leptin leptin/adiponectin ratio obesity overweight |
| url | https://www.mdpi.com/2227-9067/12/1/89 |
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