Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factors
Aim of investigation. To estimate prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with obesity and to determine its interrelation with cardiometabolic risk factors of cardio-vascular diseases (CVD) and diabetes mellitus of the 2nd type (type 2 DM).Material and methods. Retrospect...
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Gastro LLC
2012-04-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1276 |
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| author | G. A. Melnichenko A. Yu. Yeliseyeva M. V. Mayevskaya |
| author_facet | G. A. Melnichenko A. Yu. Yeliseyeva M. V. Mayevskaya |
| author_sort | G. A. Melnichenko |
| collection | DOAJ |
| description | Aim of investigation. To estimate prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with obesity and to determine its interrelation with cardiometabolic risk factors of cardio-vascular diseases (CVD) and diabetes mellitus of the 2nd type (type 2 DM).Material and methods. Retrospective analysis of case records of 560 obese patients aged 18 to 55 years was carried out. At the investigation past history, anthropometric data, level of blood pressure were analyzed, blood lipid spectrum, activity of ALT, AST, markers of viral hepatites – HbsAg, HCV-at (to rule out viral etiology of liver disease), fasting and at 120-th minute of the standard glucose tolerance test blood glucose and immunoreactive insulin were determined. Insulin resistance was estimated by HOMA-IR score. Metabolic syndrome was verified by IDF (2005) criteria. Liver US was carried out to diagnose NAFLD.Results. During investigation NAFLD was revealed in 77,7% of patients. At multi-factor analysis of variance interrelation of NAFLD with CVD and type 2 DM risk factors, such as systemic hypertension, dyslipidemia, disorders of carbohydrate metabolism and insulin resistance was confirmed.Conclusions. Study results determine necessity of more careful investigation of patients with obesity and NAFLD for early diagnostics and treatment of cardiometabolic risk factors of cardio-vascular diseases and type 2 DM. |
| format | Article |
| id | doaj-art-6d0e4a9905534ed3a36389091eaa3cb8 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2012-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-6d0e4a9905534ed3a36389091eaa3cb82025-02-10T16:14:32ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732012-04-012224553854Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factorsG. A. Melnichenko0A. Yu. Yeliseyeva1M. V. Mayevskaya2ФГБУ «Эндокринологический научный центр» Минздравсоцразвития РФФГБУ «Эндокринологический научный центр» Минздравсоцразвития РФГБОУ ВПО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздравсоцразвития РФAim of investigation. To estimate prevalence of non-alcoholic fatty liver disease (NAFLD) in patients with obesity and to determine its interrelation with cardiometabolic risk factors of cardio-vascular diseases (CVD) and diabetes mellitus of the 2nd type (type 2 DM).Material and methods. Retrospective analysis of case records of 560 obese patients aged 18 to 55 years was carried out. At the investigation past history, anthropometric data, level of blood pressure were analyzed, blood lipid spectrum, activity of ALT, AST, markers of viral hepatites – HbsAg, HCV-at (to rule out viral etiology of liver disease), fasting and at 120-th minute of the standard glucose tolerance test blood glucose and immunoreactive insulin were determined. Insulin resistance was estimated by HOMA-IR score. Metabolic syndrome was verified by IDF (2005) criteria. Liver US was carried out to diagnose NAFLD.Results. During investigation NAFLD was revealed in 77,7% of patients. At multi-factor analysis of variance interrelation of NAFLD with CVD and type 2 DM risk factors, such as systemic hypertension, dyslipidemia, disorders of carbohydrate metabolism and insulin resistance was confirmed.Conclusions. Study results determine necessity of more careful investigation of patients with obesity and NAFLD for early diagnostics and treatment of cardiometabolic risk factors of cardio-vascular diseases and type 2 DM.https://www.gastro-j.ru/jour/article/view/1276non-alcoholic fatty liver diseaseobesitymetabolic syndromerisk factors of cardio-vascular diseases |
| spellingShingle | G. A. Melnichenko A. Yu. Yeliseyeva M. V. Mayevskaya Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factors Российский журнал гастроэнтерологии, гепатологии, колопроктологии non-alcoholic fatty liver disease obesity metabolic syndrome risk factors of cardio-vascular diseases |
| title | Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factors |
| title_full | Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factors |
| title_fullStr | Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factors |
| title_full_unstemmed | Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factors |
| title_short | Prevalence of non-alcoholic fatty liver disease at obesity and its interrelation with cardio-vascular disease and 2nd type diabetes mellitus risk factors |
| title_sort | prevalence of non alcoholic fatty liver disease at obesity and its interrelation with cardio vascular disease and 2nd type diabetes mellitus risk factors |
| topic | non-alcoholic fatty liver disease obesity metabolic syndrome risk factors of cardio-vascular diseases |
| url | https://www.gastro-j.ru/jour/article/view/1276 |
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