Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut Pathology
Irritable bowel syndrome (IBS) is common in ankylosing spondylitis (AS) and may be associated with the disease. We aimed to determine the prevalence of IBS in AS patients and its association with clinical and demographic patient characteristics and with macroscopic and microscopic gut lesions. Sixty...
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2024-07-01
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| author | Nira Ferdous Johannes J. Rasker Shabnam Akhter Md. Kamruzzaman Md. Nazrul Islam |
| author_facet | Nira Ferdous Johannes J. Rasker Shabnam Akhter Md. Kamruzzaman Md. Nazrul Islam |
| author_sort | Nira Ferdous |
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| description | Irritable bowel syndrome (IBS) is common in ankylosing spondylitis (AS) and may be associated with the disease. We aimed to determine the prevalence of IBS in AS patients and its association with clinical and demographic patient characteristics and with macroscopic and microscopic gut lesions. Sixty consecutive AS patients were included in this study. Disease activity was assessed with the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and functional status with the BASFI (Bath Ankylosing Spondylitis Functional Index). The ROME III criteria were used to diagnose IBS. Macroscopic lesions were graded during colonoscopies. Biopsy specimens were taken from the terminal ileum, colon (ascending, transverse and descending) and rectum. Histological samples were scored with Cuvelier grading. The prevalence of IBS was 23.3% (14/60). The mean age of 14 IBS subjects (10 male) was 32 ± 8.50., with a higher BASDAI (<i>p</i> = 0.046). Macroscopic lesions were more frequent in IBS cases in the terminal ileum (46.2% vs. 34.9%), ascending colon (21.4% vs. 2.2%) and rectum (21.4% vs. 17.4%), with Grade 2 significantly more prevalent in the ascending colon (<i>p</i> = 0.03). Microscopic lesions did not differ among the IBS-present and -absent groups. In conclusion, the prevalence of IBS was high in AS patients and associated with higher disease activity. Grade 2 macroscopic lesions were more frequent in the ascending colon. |
| format | Article |
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| spelling | doaj-art-6d08544d227146f988e3cb402eab63fe2025-08-20T01:55:49ZengMDPI AGRheumato2674-06212024-07-014313714610.3390/rheumato4030010Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut PathologyNira Ferdous0Johannes J. Rasker1Shabnam Akhter2Md. Kamruzzaman3Md. Nazrul Islam4Department of Medicine, MH Samorita Hospital & Medical College, Tajgaon, Dhaka 1208, BangladeshFaculty of Behavioural, Management & Social Sciences, Psychology, Health and Technology, University of Twente, P.O. Box 217, 7500AE Enschede, The NetherlandsDepartment of Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka 1000, BangladeshDepartment of Statistics, Jagannath University, Dhaka 1100, BangladeshModern One Stop Arthritis Care & Research Center®, Dhaka 1209, BangladeshIrritable bowel syndrome (IBS) is common in ankylosing spondylitis (AS) and may be associated with the disease. We aimed to determine the prevalence of IBS in AS patients and its association with clinical and demographic patient characteristics and with macroscopic and microscopic gut lesions. Sixty consecutive AS patients were included in this study. Disease activity was assessed with the BASDAI (Bath Ankylosing Spondylitis Disease Activity Index) and functional status with the BASFI (Bath Ankylosing Spondylitis Functional Index). The ROME III criteria were used to diagnose IBS. Macroscopic lesions were graded during colonoscopies. Biopsy specimens were taken from the terminal ileum, colon (ascending, transverse and descending) and rectum. Histological samples were scored with Cuvelier grading. The prevalence of IBS was 23.3% (14/60). The mean age of 14 IBS subjects (10 male) was 32 ± 8.50., with a higher BASDAI (<i>p</i> = 0.046). Macroscopic lesions were more frequent in IBS cases in the terminal ileum (46.2% vs. 34.9%), ascending colon (21.4% vs. 2.2%) and rectum (21.4% vs. 17.4%), with Grade 2 significantly more prevalent in the ascending colon (<i>p</i> = 0.03). Microscopic lesions did not differ among the IBS-present and -absent groups. In conclusion, the prevalence of IBS was high in AS patients and associated with higher disease activity. Grade 2 macroscopic lesions were more frequent in the ascending colon.https://www.mdpi.com/2674-0621/4/3/10ankylosing spondylitisirritable bowel syndromegut lesionsmacroscopic and microscopic pathology |
| spellingShingle | Nira Ferdous Johannes J. Rasker Shabnam Akhter Md. Kamruzzaman Md. Nazrul Islam Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut Pathology Rheumato ankylosing spondylitis irritable bowel syndrome gut lesions macroscopic and microscopic pathology |
| title | Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut Pathology |
| title_full | Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut Pathology |
| title_fullStr | Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut Pathology |
| title_full_unstemmed | Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut Pathology |
| title_short | Prevalence of Irritable Bowel Syndrome in Ankylosing Spondylitis and Its Association with Clinical and Demographic Findings and Gut Pathology |
| title_sort | prevalence of irritable bowel syndrome in ankylosing spondylitis and its association with clinical and demographic findings and gut pathology |
| topic | ankylosing spondylitis irritable bowel syndrome gut lesions macroscopic and microscopic pathology |
| url | https://www.mdpi.com/2674-0621/4/3/10 |
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