Polydatin attenuates Alzheimer’s disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects

Polydatin attenuates Alzheimer’s disease induced by aluminum chloride in rats: evidence for its antioxidant and anti-inflammatory effects

BackgroundConsidering the complex pathophysiological mechanisms behind Alzheimer’s disease (AD), a few drugs for managing related cognitive symptoms have been approved. The phytochemical resveratrol has shown promising anti-inflammatory and antioxidant effects in AD, but it has low bioavailability....

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Bibliographic Details
Main Authors: Seyede Nazanin Zarneshan, Sajad Fakhri, Amir Kiani, Fatemeh Abbaszadeh, Seyede Zahra Hosseini, Ehsan Mohammadi-Noori, Javier Echeverría
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s disease
aluminum chloride
polydatin
inflammation
matrix metalloproteinase
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1574323/full
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