Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy
Introduction. Transrectal biopsy under US-control has been standard diagnostic method for prostate cancer (PCa) detection for over 30 years. However, TRUS-guided biopsy is not without well-known drawbacks. MR-targeted biopsy methods were proposed to eliminate the drawbacks and improve detection rate...
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Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education
2023-01-01
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| Series: | Вестник урологии |
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| Online Access: | https://www.urovest.ru/jour/article/view/628 |
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| author | V. S. Petov A. K. Bazarkin E. S. Krupinov A. O. Morozov M. S. Taratkin A. F. Abdusalamov A. V. Amosov D. V. Enikeev |
| author_facet | V. S. Petov A. K. Bazarkin E. S. Krupinov A. O. Morozov M. S. Taratkin A. F. Abdusalamov A. V. Amosov D. V. Enikeev |
| author_sort | V. S. Petov |
| collection | DOAJ |
| description | Introduction. Transrectal biopsy under US-control has been standard diagnostic method for prostate cancer (PCa) detection for over 30 years. However, TRUS-guided biopsy is not without well-known drawbacks. MR-targeted biopsy methods were proposed to eliminate the drawbacks and improve detection rate of clinically significant Pca. Cognitive and mpMR/US-fusion biopsies have become the most widely used MR-targeted biopsies. However, there are contradictory data on detection of clinically significant Pca when comparing mpMR/US-fusion and cognitive biopsies.Objective. To compare the detection rate of clinically significant prostate cancer performing cognitive and mpMR/US-fusion biopsies.Materials and methods. Inclusion criteria: PSA > 2.0 ng/ml and/or a positive DRE, and/or a suspicious lesion on TRUS, and PI-RADSv2.1 score ≥ 3. The outcomes evaluated are the detection of clinically significant Pca (ISUP ≥ 2), the overall PСa detection, the detection of clinically insignificant Pca, histological yield (proportion of positive cores, maximum cancer core length).Results. Retrospective data analysis was performed: cognitive biopsy was performed in 102 patients and mpMR/US-fusion biopsy in 176 patients. The median age was 63 years, prostate volume 46 cc. The median PSA was 6.4 ng/ml in the mpMR/US-fusion and 6.7 ng/ml in the cognitive biopsy group. MpMR/US-fusion and cognitive biopsies were comparable about the detection rate of clinically significant (30.3% vs 25.0%; p=0.329) and overall Pca detection rate (50.5% and 42.1%; p = 0.176). It was detected to be less clinically insignificant Pca in the cognitive biopsy group (11.8% vs. 25.5%; p = 0.007). The proportion of positive cores (30.5% and 29.5% respectively; p = 0.754) and maximum cancer core length (6.6 mm vs 7.6 mm; p = 0.320) were equal when comparing cognitive and mpMR/US-fusion biopsies. The proportion of positive cores with clinically significant Pca was higher in the cognitive biopsy group (18.6% vs 13.1%; p = 0.029).Conclusion. Both cognitive and mpMR/US-fusion biopsies are equally accurate for clinically significant Pca detection. Therefore, cognitive biopsy may be an alternative to mpMR/US-fusion biopsy in hospitals where mpMR/US-fusion technology is not currently available. |
| format | Article |
| id | doaj-art-6cfc9d67f8b646b8a976eed863cd7396 |
| institution | Kabale University |
| issn | 2308-6424 |
| language | Russian |
| publishDate | 2023-01-01 |
| publisher | Ministry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional Education |
| record_format | Article |
| series | Вестник урологии |
| spelling | doaj-art-6cfc9d67f8b646b8a976eed863cd73962025-08-20T03:43:33ZrusMinistry of Health of Russian Federation, Rostov State Medical University, State Budget Educational Institute of Higher Professional EducationВестник урологии2308-64242023-01-01104889710.21886/2308-6424-2022-10-4-88-97412Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsyV. S. Petov0A. K. Bazarkin1E. S. Krupinov2A. O. Morozov3M. S. Taratkin4A. F. Abdusalamov5A. V. Amosov6D. V. Enikeev7Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University); Medical University of ViennaIntroduction. Transrectal biopsy under US-control has been standard diagnostic method for prostate cancer (PCa) detection for over 30 years. However, TRUS-guided biopsy is not without well-known drawbacks. MR-targeted biopsy methods were proposed to eliminate the drawbacks and improve detection rate of clinically significant Pca. Cognitive and mpMR/US-fusion biopsies have become the most widely used MR-targeted biopsies. However, there are contradictory data on detection of clinically significant Pca when comparing mpMR/US-fusion and cognitive biopsies.Objective. To compare the detection rate of clinically significant prostate cancer performing cognitive and mpMR/US-fusion biopsies.Materials and methods. Inclusion criteria: PSA > 2.0 ng/ml and/or a positive DRE, and/or a suspicious lesion on TRUS, and PI-RADSv2.1 score ≥ 3. The outcomes evaluated are the detection of clinically significant Pca (ISUP ≥ 2), the overall PСa detection, the detection of clinically insignificant Pca, histological yield (proportion of positive cores, maximum cancer core length).Results. Retrospective data analysis was performed: cognitive biopsy was performed in 102 patients and mpMR/US-fusion biopsy in 176 patients. The median age was 63 years, prostate volume 46 cc. The median PSA was 6.4 ng/ml in the mpMR/US-fusion and 6.7 ng/ml in the cognitive biopsy group. MpMR/US-fusion and cognitive biopsies were comparable about the detection rate of clinically significant (30.3% vs 25.0%; p=0.329) and overall Pca detection rate (50.5% and 42.1%; p = 0.176). It was detected to be less clinically insignificant Pca in the cognitive biopsy group (11.8% vs. 25.5%; p = 0.007). The proportion of positive cores (30.5% and 29.5% respectively; p = 0.754) and maximum cancer core length (6.6 mm vs 7.6 mm; p = 0.320) were equal when comparing cognitive and mpMR/US-fusion biopsies. The proportion of positive cores with clinically significant Pca was higher in the cognitive biopsy group (18.6% vs 13.1%; p = 0.029).Conclusion. Both cognitive and mpMR/US-fusion biopsies are equally accurate for clinically significant Pca detection. Therefore, cognitive biopsy may be an alternative to mpMR/US-fusion biopsy in hospitals where mpMR/US-fusion technology is not currently available.https://www.urovest.ru/jour/article/view/628prostate cancerbiopsympmr/us-fusion biopsycognitive biopsyhistologyeffectiveness |
| spellingShingle | V. S. Petov A. K. Bazarkin E. S. Krupinov A. O. Morozov M. S. Taratkin A. F. Abdusalamov A. V. Amosov D. V. Enikeev Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy Вестник урологии prostate cancer biopsy mpmr/us-fusion biopsy cognitive biopsy histology effectiveness |
| title | Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy |
| title_full | Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy |
| title_fullStr | Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy |
| title_full_unstemmed | Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy |
| title_short | Retrospective analysis of prostate cancer detection using mpMR/US-fusion and cognitive biopsy |
| title_sort | retrospective analysis of prostate cancer detection using mpmr us fusion and cognitive biopsy |
| topic | prostate cancer biopsy mpmr/us-fusion biopsy cognitive biopsy histology effectiveness |
| url | https://www.urovest.ru/jour/article/view/628 |
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