Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition
Summary: Rhythm perception is considered a conserved trait across species, and musical rhythm exposure (MRE) has been demonstrated to enhance cognitive functions in healthy individuals. Alzheimer’s disease (AD), characterized by cognitive decline and pathological degeneration, may potentially be del...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-08-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225014294 |
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| author | Junjun Li Chuanjiang Wu Qinjun Liu Mingqi Liu Ting Liu Airui Li Guangchao Fu Zhiyong Zou Daqing Guo Ke Chen Yang Xia Dezhong Yao |
| author_facet | Junjun Li Chuanjiang Wu Qinjun Liu Mingqi Liu Ting Liu Airui Li Guangchao Fu Zhiyong Zou Daqing Guo Ke Chen Yang Xia Dezhong Yao |
| author_sort | Junjun Li |
| collection | DOAJ |
| description | Summary: Rhythm perception is considered a conserved trait across species, and musical rhythm exposure (MRE) has been demonstrated to enhance cognitive functions in healthy individuals. Alzheimer’s disease (AD), characterized by cognitive decline and pathological degeneration, may potentially be delayed by MRE. In this study, the APP/PS1 AD mouse model was exposed to Mozart’s K.448 rhythm for six months, with APP/PS1 and wild-type C57BL/6J mice serving as controls. The Morris water maze test was employed to assess the impact of MRE on spatial learning and memory. Pathological damage was evaluated through amyloid-beta and phosphorylated tau levels. Additionally, hippocampal microglia activation, inflammatory markers, and gut microbiota composition were analyzed. The study revealed that MRE improves cognitive function, reduces amyloid plaque accumulation, suppresses microglial activation and neuroinflammation, and modulates gut microbiota composition. This suggests that MRE offers a promising non-pharmacological approach to slowing cognitive decline and pathological damage in AD. |
| format | Article |
| id | doaj-art-6cf6fae3fe9e4e438baf21374f3bfa52 |
| institution | Kabale University |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-6cf6fae3fe9e4e438baf21374f3bfa522025-08-20T03:58:18ZengElsevieriScience2589-00422025-08-0128811316810.1016/j.isci.2025.113168Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognitionJunjun Li0Chuanjiang Wu1Qinjun Liu2Mingqi Liu3Ting Liu4Airui Li5Guangchao Fu6Zhiyong Zou7Daqing Guo8Ke Chen9Yang Xia10Dezhong Yao11The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, ChinaThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; Department of Neurosurgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China; Corresponding authorThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; Department of Neurosurgery, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 611731, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, China; Corresponding authorThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China; School of Electrical Engineering, Zhengzhou University, Zhengzhou, China; Research Unit of NeuroInformation, Chinese Academy of Medical Sciences, Chengdu, China; Corresponding authorSummary: Rhythm perception is considered a conserved trait across species, and musical rhythm exposure (MRE) has been demonstrated to enhance cognitive functions in healthy individuals. Alzheimer’s disease (AD), characterized by cognitive decline and pathological degeneration, may potentially be delayed by MRE. In this study, the APP/PS1 AD mouse model was exposed to Mozart’s K.448 rhythm for six months, with APP/PS1 and wild-type C57BL/6J mice serving as controls. The Morris water maze test was employed to assess the impact of MRE on spatial learning and memory. Pathological damage was evaluated through amyloid-beta and phosphorylated tau levels. Additionally, hippocampal microglia activation, inflammatory markers, and gut microbiota composition were analyzed. The study revealed that MRE improves cognitive function, reduces amyloid plaque accumulation, suppresses microglial activation and neuroinflammation, and modulates gut microbiota composition. This suggests that MRE offers a promising non-pharmacological approach to slowing cognitive decline and pathological damage in AD.http://www.sciencedirect.com/science/article/pii/S2589004225014294NeuroscienceBehavioral neuroscienceMicrobiome |
| spellingShingle | Junjun Li Chuanjiang Wu Qinjun Liu Mingqi Liu Ting Liu Airui Li Guangchao Fu Zhiyong Zou Daqing Guo Ke Chen Yang Xia Dezhong Yao Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition iScience Neuroscience Behavioral neuroscience Microbiome |
| title | Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition |
| title_full | Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition |
| title_fullStr | Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition |
| title_full_unstemmed | Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition |
| title_short | Mozart’s rhythm influence on Alzheimer’s disease progression via modulation of pathological damage and cognition |
| title_sort | mozart s rhythm influence on alzheimer s disease progression via modulation of pathological damage and cognition |
| topic | Neuroscience Behavioral neuroscience Microbiome |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225014294 |
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