Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.

The cascade of care is a model for evaluating patient retention across sequential stages of care required to achieve a successful treatment outcome. This approach was first used to evaluate HIV care and has since been applied to other diseases. The tuberculosis (TB) community has only recently start...

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Main Authors: Ramnath Subbaraman, Ruvandhi R Nathavitharana, Kenneth H Mayer, Srinath Satyanarayana, Vineet K Chadha, Nimalan Arinaminpathy, Madhukar Pai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-02-01
Series:PLoS Medicine
Online Access:https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002754&type=printable
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author Ramnath Subbaraman
Ruvandhi R Nathavitharana
Kenneth H Mayer
Srinath Satyanarayana
Vineet K Chadha
Nimalan Arinaminpathy
Nimalan Arinaminpathy
Madhukar Pai
author_facet Ramnath Subbaraman
Ruvandhi R Nathavitharana
Kenneth H Mayer
Srinath Satyanarayana
Vineet K Chadha
Nimalan Arinaminpathy
Nimalan Arinaminpathy
Madhukar Pai
author_sort Ramnath Subbaraman
collection DOAJ
description The cascade of care is a model for evaluating patient retention across sequential stages of care required to achieve a successful treatment outcome. This approach was first used to evaluate HIV care and has since been applied to other diseases. The tuberculosis (TB) community has only recently started using care cascade analyses to quantify gaps in quality of care. In this article, we describe methods for estimating gaps (patient losses) and steps (patients retained) in the care cascade for active TB disease. We highlight approaches for overcoming challenges in constructing the TB care cascade, which include difficulties in estimating the population-level burden of disease and the diagnostic gap due to the limited sensitivity of TB diagnostic tests. We also describe potential uses of this model for evaluating the impact of interventions to improve case finding, diagnosis, linkage to care, retention in care, and post-treatment monitoring of TB patients.
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id doaj-art-6cf6f2ec07b741eea04bb0856b4f1b43
institution OA Journals
issn 1549-1277
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language English
publishDate 2019-02-01
publisher Public Library of Science (PLoS)
record_format Article
series PLoS Medicine
spelling doaj-art-6cf6f2ec07b741eea04bb0856b4f1b432025-08-20T02:23:18ZengPublic Library of Science (PLoS)PLoS Medicine1549-12771549-16762019-02-01162e100275410.1371/journal.pmed.1002754Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.Ramnath SubbaramanRuvandhi R NathavitharanaKenneth H MayerSrinath SatyanarayanaVineet K ChadhaNimalan ArinaminpathyNimalan ArinaminpathyMadhukar PaiThe cascade of care is a model for evaluating patient retention across sequential stages of care required to achieve a successful treatment outcome. This approach was first used to evaluate HIV care and has since been applied to other diseases. The tuberculosis (TB) community has only recently started using care cascade analyses to quantify gaps in quality of care. In this article, we describe methods for estimating gaps (patient losses) and steps (patients retained) in the care cascade for active TB disease. We highlight approaches for overcoming challenges in constructing the TB care cascade, which include difficulties in estimating the population-level burden of disease and the diagnostic gap due to the limited sensitivity of TB diagnostic tests. We also describe potential uses of this model for evaluating the impact of interventions to improve case finding, diagnosis, linkage to care, retention in care, and post-treatment monitoring of TB patients.https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002754&type=printable
spellingShingle Ramnath Subbaraman
Ruvandhi R Nathavitharana
Kenneth H Mayer
Srinath Satyanarayana
Vineet K Chadha
Nimalan Arinaminpathy
Nimalan Arinaminpathy
Madhukar Pai
Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.
PLoS Medicine
title Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.
title_full Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.
title_fullStr Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.
title_full_unstemmed Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.
title_short Constructing care cascades for active tuberculosis: A strategy for program monitoring and identifying gaps in quality of care.
title_sort constructing care cascades for active tuberculosis a strategy for program monitoring and identifying gaps in quality of care
url https://journals.plos.org/plosmedicine/article/file?id=10.1371/journal.pmed.1002754&type=printable
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