Using X-ray velocimetry to measure lung function and assess the efficacy of a pseudomonas aeruginosa bacteriophage therapy for cystic fibrosis

Using X-ray velocimetry to measure lung function and assess the efficacy of a pseudomonas aeruginosa bacteriophage therapy for cystic fibrosis

Abstract Phase contrast x-ray imaging (PCXI) provides high-contrast images of weakly-attenuating structures like the lungs. PCXI, when paired with 4D X-ray Velocimetry (XV), can measure regional lung function and non-invasively assess the efficacy of emerging therapeutics. Bacteriophage therapy is a...

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Bibliographic Details
Main Authors: Stephanie A. Harker, Melissa Preissner, Rachel Yoon Chang, David Trevascus, Chengxi Liu, Yuncheng Wang, Michael Y. T. Chow, Patricia Cmielewski, Nicole Reyne, Ying Ying How, James A. Pollock, Mitzi Klein, Christopher A. Wright, Stephen Dubsky, Martin Donnelley, Hak-Kim Chan, Kaye S. Morgan
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Scientific Reports
Subjects:
Cystic Fibrosis
Bacteriophage
X-ray Velocimetry
Phase contrast
Computed tomography
Online Access:https://doi.org/10.1038/s41598-024-80326-0
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