Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV

Aberrant DNA methylation of genes regulating CD4+ T cell HIV‐1 reservoir in women with HIV

Abstract Background The HIV‐1 reservoir in CD4+ T cells (HRCD4) pose a major challenge to curing HIV, with many of its mechanisms still unclear. HIV‐1 DNA integration and immune responses may alter the host's epigenetic landscape, potentially silencing HIV‐1 replication. Methods This study used...

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Main Authors: Ke Xu, Xinyu Zhang, Kesava Asam, Bryan C. Quach, Grier P. Page, Deborah Konkle‐Parker, Claudia Martinez, Cecile D. Lahiri, Elizabeth F. Topper, Mardge H. Cohen, Seble G. Kassaye, Jack DeHovitz, Mark H. Kuniholm, Nancie M. Archin, Amir Valizadeh, Phyllis C. Tien, Vincent C. Marconi, Dana B. Hancock, Eric O. Johnson, Bradley E. Aouizerat
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Clinical and Translational Medicine
Online Access:https://doi.org/10.1002/ctm2.70267
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