Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury

Activated alpha 9 integrin expression enables sensory pathway reconstruction after spinal cord injury

Abstract Full recovery from spinal cord injury requires axon regeneration to re-establish motor and sensory pathways. In mammals, the failure of sensory and motor axon regeneration has many causes intrinsic and extrinsic to neurons, amongst which is the lack of adhesion molecules needed to interact...

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Main Authors: Katerina Stepankova, Barbora Smejkalova, Lucia Machova Urdzikova, Katerina Haveliková, Fred de Winter, Stepanka Suchankova, Joost Verhaagen, Vit Herynek, Rostislav Turecek, Jessica Kwok, James Fawcett, Pavla Jendelova
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Acta Neuropathologica Communications
Subjects:
Spinal cord injury
Axon regeneration
Integrins
Kindlin
AAV vectors
Sensory testing
Online Access:https://doi.org/10.1186/s40478-025-01995-0
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