Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury
Methylmercury (MeHg), an environmental toxicant primarily found in fish and seafood, poses a dilemma to both consumers and regulatory authorities, given the nutritional benefits of fish consumption versus the possible adverse neurological damage. Several studies have shown that MeHg toxicity is infl...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Toxicology |
| Online Access: | http://dx.doi.org/10.1155/2011/721987 |
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| author | Parvinder Kaur Michael Aschner Tore Syversen |
| author_facet | Parvinder Kaur Michael Aschner Tore Syversen |
| author_sort | Parvinder Kaur |
| collection | DOAJ |
| description | Methylmercury (MeHg), an environmental toxicant primarily found in fish and seafood, poses a dilemma to both consumers and regulatory authorities, given the nutritional benefits of fish consumption versus the possible adverse neurological damage. Several studies have shown that MeHg toxicity is influenced by a number of biochemical factors, such as glutathione (GSH), fatty acids, vitamins, and essential elements, but the cellular mechanisms underlying these complex interactions have not yet been fully elucidated. The objective of this paper is to outline the cellular response to dietary nutrients, as well as to describe the neurotoxic exposures to MeHg. In order to determine the cellular mechanism(s) of toxicity, the effect of pretreatment with biochemical factors (e.g., N-acetyl cysteine, (NAC); diethyl maleate, (DEM); docosahexaenoic acid, (DHA); selenomethionine, SeM; Trolox) and MeHg treatment on intercellular antioxidant status, MeHg content, and other endpoints was evaluated. This paper emphasizes that the protection against oxidative stress offered by these biochemical factors is among one of the major mechanisms responsible for conferring neuroprotection. It is therefore critical to ascertain the cellular mechanisms associated with various dietary nutrients as well as to determine the potential effects of neurotoxic exposures for accurately assessing the risks and benefits associated with fish consumption. |
| format | Article |
| id | doaj-art-6ce6cd4992f2464593992d19aad571e7 |
| institution | Kabale University |
| issn | 1687-8191 1687-8205 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Toxicology |
| spelling | doaj-art-6ce6cd4992f2464593992d19aad571e72025-02-03T01:09:29ZengWileyJournal of Toxicology1687-81911687-82052011-01-01201110.1155/2011/721987721987Biochemical Factors Modulating Cellular Neurotoxicity of MethylmercuryParvinder Kaur0Michael Aschner1Tore Syversen2Department of Neuroscience, Norwegian University of Science and Technology, 7489 Trondheim, NorwayDepartments of Pediatrics and Pharmacology and The Kennedy Center for Research on Human Development, Vanderbilt University Medical Center, B-3307 Medical Center North, 1162 21st Avenue, Nashville, TN 37232-2495, USADepartment of Neuroscience, Faculty of Medicine, Norwegian University of Science and Technology, Olav Kyrres Gate 3, 7489 Trondheim, NorwayMethylmercury (MeHg), an environmental toxicant primarily found in fish and seafood, poses a dilemma to both consumers and regulatory authorities, given the nutritional benefits of fish consumption versus the possible adverse neurological damage. Several studies have shown that MeHg toxicity is influenced by a number of biochemical factors, such as glutathione (GSH), fatty acids, vitamins, and essential elements, but the cellular mechanisms underlying these complex interactions have not yet been fully elucidated. The objective of this paper is to outline the cellular response to dietary nutrients, as well as to describe the neurotoxic exposures to MeHg. In order to determine the cellular mechanism(s) of toxicity, the effect of pretreatment with biochemical factors (e.g., N-acetyl cysteine, (NAC); diethyl maleate, (DEM); docosahexaenoic acid, (DHA); selenomethionine, SeM; Trolox) and MeHg treatment on intercellular antioxidant status, MeHg content, and other endpoints was evaluated. This paper emphasizes that the protection against oxidative stress offered by these biochemical factors is among one of the major mechanisms responsible for conferring neuroprotection. It is therefore critical to ascertain the cellular mechanisms associated with various dietary nutrients as well as to determine the potential effects of neurotoxic exposures for accurately assessing the risks and benefits associated with fish consumption.http://dx.doi.org/10.1155/2011/721987 |
| spellingShingle | Parvinder Kaur Michael Aschner Tore Syversen Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury Journal of Toxicology |
| title | Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury |
| title_full | Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury |
| title_fullStr | Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury |
| title_full_unstemmed | Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury |
| title_short | Biochemical Factors Modulating Cellular Neurotoxicity of Methylmercury |
| title_sort | biochemical factors modulating cellular neurotoxicity of methylmercury |
| url | http://dx.doi.org/10.1155/2011/721987 |
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