Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis)
Abstract Background Current endogenous indicators utilised in avian medicine are not sensitive enough to detect renal disease in its early stages. Alternative markers ought to be examined as a result. The aim is to investigate the accuracy of limited-sampling models for glomerular filtration rate (G...
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BMC
2025-01-01
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| Series: | BMC Veterinary Research |
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| Online Access: | https://doi.org/10.1186/s12917-024-04454-5 |
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| author | Matilde Vernaccini Micaela Sgorbini Lucia De Marchi Maria Irene Pacini Renato Ceccherelli Leonardo Gaci Scaletti Francesca Bonelli Valentina Meucci |
| author_facet | Matilde Vernaccini Micaela Sgorbini Lucia De Marchi Maria Irene Pacini Renato Ceccherelli Leonardo Gaci Scaletti Francesca Bonelli Valentina Meucci |
| author_sort | Matilde Vernaccini |
| collection | DOAJ |
| description | Abstract Background Current endogenous indicators utilised in avian medicine are not sensitive enough to detect renal disease in its early stages. Alternative markers ought to be examined as a result. The aim is to investigate the accuracy of limited-sampling models for glomerular filtration rate (GFR) in adult seagulls using plasma clearance of iohexol (IOX). Results We compared the GFR estimated from the plasma concentration of IOX at 3 sampling times, known as limited sampling models, with that estimated from the plasma concentration of IOX at 6 sampling times (reference model). The reference model’s mean ± SD for GFR was 6.88 ± 2.46 mL/min/kg and did not considerably differ from the GFR predicted by the limited-sampling models. Model 4, in which GFR was estimated using plasma IOX concentrations at 5, 15, and 90 min after IOX administration, had the smallest GFR bias compared to the reference model. Conclusions The findings revealed that IOX plasma clearance was a reliable, accurate, and clinically applicable approach to calculating seagull GFR. This strategy might help with the validation and subsequent development of clinical renal biomarkers. |
| format | Article |
| id | doaj-art-6ce50fc0c2cd4fa9ad6363aa9c62e3ca |
| institution | OA Journals |
| issn | 1746-6148 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Veterinary Research |
| spelling | doaj-art-6ce50fc0c2cd4fa9ad6363aa9c62e3ca2025-08-20T02:35:36ZengBMCBMC Veterinary Research1746-61482025-01-012111610.1186/s12917-024-04454-5Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis)Matilde Vernaccini0Micaela Sgorbini1Lucia De Marchi2Maria Irene Pacini3Renato Ceccherelli4Leonardo Gaci Scaletti5Francesca Bonelli6Valentina Meucci7Department of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, University of PisaDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, University of PisaDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, University of PisaLipu ODVLipu ODVDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, University of PisaDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, University of PisaDepartment of Veterinary Sciences, Veterinary Teaching Hospital “Mario Modenato”, University of PisaAbstract Background Current endogenous indicators utilised in avian medicine are not sensitive enough to detect renal disease in its early stages. Alternative markers ought to be examined as a result. The aim is to investigate the accuracy of limited-sampling models for glomerular filtration rate (GFR) in adult seagulls using plasma clearance of iohexol (IOX). Results We compared the GFR estimated from the plasma concentration of IOX at 3 sampling times, known as limited sampling models, with that estimated from the plasma concentration of IOX at 6 sampling times (reference model). The reference model’s mean ± SD for GFR was 6.88 ± 2.46 mL/min/kg and did not considerably differ from the GFR predicted by the limited-sampling models. Model 4, in which GFR was estimated using plasma IOX concentrations at 5, 15, and 90 min after IOX administration, had the smallest GFR bias compared to the reference model. Conclusions The findings revealed that IOX plasma clearance was a reliable, accurate, and clinically applicable approach to calculating seagull GFR. This strategy might help with the validation and subsequent development of clinical renal biomarkers.https://doi.org/10.1186/s12917-024-04454-5SeagullIohexolGlomerular filtration rate |
| spellingShingle | Matilde Vernaccini Micaela Sgorbini Lucia De Marchi Maria Irene Pacini Renato Ceccherelli Leonardo Gaci Scaletti Francesca Bonelli Valentina Meucci Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis) BMC Veterinary Research Seagull Iohexol Glomerular filtration rate |
| title | Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis) |
| title_full | Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis) |
| title_fullStr | Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis) |
| title_full_unstemmed | Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis) |
| title_short | Evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls (Larus michahellis) |
| title_sort | evaluation of glomerular filtration rate estimation through plasma clearance of iohexol in seagulls larus michahellis |
| topic | Seagull Iohexol Glomerular filtration rate |
| url | https://doi.org/10.1186/s12917-024-04454-5 |
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