Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin
To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n=169) and control subjects (n=73) were divided into 2 subgroups, one of n...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/612038 |
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| author | Filipa Mascarenhas-Melo José Sereno Edite Teixeira-Lemos Daniela Marado Filipe Palavra Rui Pinto Petronila Rocha-Pereira Frederico Teixeira Flávio Reis |
| author_facet | Filipa Mascarenhas-Melo José Sereno Edite Teixeira-Lemos Daniela Marado Filipe Palavra Rui Pinto Petronila Rocha-Pereira Frederico Teixeira Flávio Reis |
| author_sort | Filipa Mascarenhas-Melo |
| collection | DOAJ |
| description | To evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n=169) and control subjects (n=73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients’ subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients’ subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin. |
| format | Article |
| id | doaj-art-6cdebb13c65c4119b184e583e2cc8b54 |
| institution | OA Journals |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6cdebb13c65c4119b184e583e2cc8b542025-08-20T02:24:03ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/612038612038Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and AdiponectinFilipa Mascarenhas-Melo0José Sereno1Edite Teixeira-Lemos2Daniela Marado3Filipe Palavra4Rui Pinto5Petronila Rocha-Pereira6Frederico Teixeira7Flávio Reis8Laboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalESAV and Educational Technologies and Health Study Center, Polytechnic Institute of Viseu, 3504-510 Viseu, PortugalInternal Medicine Department, General Hospital, University and Hospital Centre of Coimbra, 3041-801 São Martinho do Bispo, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalPharmacology and Pharmacotoxicology Unit, Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, PortugalResearch Centre for Health Sciences, Beira Interior University, 6201-001 Covilhã, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalLaboratory of Pharmacology & Experimental Therapeutics, IBILI, Faculty of Medicine, Sub-Unit 1 (Pólo III), University of Coimbra, 3000-548 Coimbra, PortugalTo evaluate the impact of low levels of high density lipoprotein cholesterol (HDL-c) on patients with LDL-c average levels, focusing on oxidative, lipidic, and inflammatory profiles. Patients with cardiovascular risk factors (n=169) and control subjects (n=73) were divided into 2 subgroups, one of normal HDL-c and the other of low HDL-c levels. The following data was analyzed: BP, BMI, waist circumference and serum glucose Total-c, TGs, LDL-c, oxidized LDL, total HDL-c and subpopulations (small, intermediate, and large), paraoxonase-1 (PON1) activity, hsCRP, uric acid, TNF-α, adiponectin, VEGF, and iCAM1. In the control subgroup with low HDL-c levels, significantly higher values of BP and TGs and lower values of PON1 activity and adiponectin were found, versus control normal HDL-c subgroup. However, differences in patients’ subgroups were clearly more pronounced. Indeed, low HDL-c subgroup presented increased HbA1c, TGs, non-HDL-c, Ox-LDL, hsCRP, VEGF, and small HDL-c and reduced adiponectin and large HDL. In addition, Ox-LDL, large-HDL-c, and adiponectin presented interesting correlations with classical and nonclassical markers, mainly in the normal HDL-c patients’ subgroup. In conclusion, despite LDL-c average levels, low HDL-c concentrations seem to be associated with a poor cardiometabolic profile in a population with cardiovascular risk factors, which is better evidenced by traditional and nontraditional CV biomarkers, including Ox-LDL, large HDL-c, and adiponectin.http://dx.doi.org/10.1155/2013/612038 |
| spellingShingle | Filipa Mascarenhas-Melo José Sereno Edite Teixeira-Lemos Daniela Marado Filipe Palavra Rui Pinto Petronila Rocha-Pereira Frederico Teixeira Flávio Reis Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin Mediators of Inflammation |
| title | Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin |
| title_full | Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin |
| title_fullStr | Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin |
| title_full_unstemmed | Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin |
| title_short | Implication of Low HDL-c Levels in Patients with Average LDL-c Levels: A Focus on Oxidized LDL, Large HDL Subpopulation, and Adiponectin |
| title_sort | implication of low hdl c levels in patients with average ldl c levels a focus on oxidized ldl large hdl subpopulation and adiponectin |
| url | http://dx.doi.org/10.1155/2013/612038 |
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