Plant-derived products as anti-leishmanials which target mitochondria: a review
Abstract Background The global incidences of leishmaniasis are increasing due to changing environmental conditions and growing poverty. Leishmaniasis, caused by the Leishmania parasite, presents itself in six different clinical forms, the cutaneous and the visceral diseases being the most prevalen...
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Cambridge University Press
2025-01-01
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| Series: | Expert Reviews in Molecular Medicine |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S1462399425000080/type/journal_article |
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| author | Chandrima Shaha |
| author_facet | Chandrima Shaha |
| author_sort | Chandrima Shaha |
| collection | DOAJ |
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Abstract
Background
The global incidences of leishmaniasis are increasing due to changing environmental conditions and growing poverty. Leishmaniasis, caused by the Leishmania parasite, presents itself in six different clinical forms, the cutaneous and the visceral diseases being the most prevalent. While the cutaneous form causes disfigurement, the visceral form could be fatal if not treated. With no available vaccines combined with serious side effects of current medications and emerging drug resistance, it is crucial to discover new drugs whether as novel compounds or as repurposed existing pharmaceuticals. In the realm of drug development, mitochondria are recognized as important pharmacological targets due to their critical role in energy control, which, when disrupted, leads to irreversible cell damage. Certain plant-based compounds able to target the parasite mitochondrion, have been studied for their potential anti-leishmanial effects.
Search results
These compounds have shown promising effects in eliminating the Leishmania parasite. Artemisinin and chloroquine, two anti-malarial drugs that target mitochondria, exert strong anti-leishmanial effectiveness in both in vitro cultures and in vivo animal models. Quinolones, coumarins and quercetin are other compounds with leishmanicidal properties, which disrupt mitochondrial activity to effectively eliminate parasites in animal models of the disease and could be considered as potential drugs.
Conclusions
Therefore, plant-based compounds hold promise as potential candidates for anti-leishmanial drug development.
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| format | Article |
| id | doaj-art-6cdeaf0dcf7a46e5b6dcb915bda1159e |
| institution | Kabale University |
| issn | 1462-3994 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Expert Reviews in Molecular Medicine |
| spelling | doaj-art-6cdeaf0dcf7a46e5b6dcb915bda1159e2025-08-20T12:57:28ZengCambridge University PressExpert Reviews in Molecular Medicine1462-39942025-01-012710.1017/erm.2025.8Plant-derived products as anti-leishmanials which target mitochondria: a reviewChandrima Shaha0https://orcid.org/0000-0002-8185-3501Division of Infectious Diseases and Immunology, Indian Institute of Chemical Biology, Kolkata, India Abstract Background The global incidences of leishmaniasis are increasing due to changing environmental conditions and growing poverty. Leishmaniasis, caused by the Leishmania parasite, presents itself in six different clinical forms, the cutaneous and the visceral diseases being the most prevalent. While the cutaneous form causes disfigurement, the visceral form could be fatal if not treated. With no available vaccines combined with serious side effects of current medications and emerging drug resistance, it is crucial to discover new drugs whether as novel compounds or as repurposed existing pharmaceuticals. In the realm of drug development, mitochondria are recognized as important pharmacological targets due to their critical role in energy control, which, when disrupted, leads to irreversible cell damage. Certain plant-based compounds able to target the parasite mitochondrion, have been studied for their potential anti-leishmanial effects. Search results These compounds have shown promising effects in eliminating the Leishmania parasite. Artemisinin and chloroquine, two anti-malarial drugs that target mitochondria, exert strong anti-leishmanial effectiveness in both in vitro cultures and in vivo animal models. Quinolones, coumarins and quercetin are other compounds with leishmanicidal properties, which disrupt mitochondrial activity to effectively eliminate parasites in animal models of the disease and could be considered as potential drugs. Conclusions Therefore, plant-based compounds hold promise as potential candidates for anti-leishmanial drug development. https://www.cambridge.org/core/product/identifier/S1462399425000080/type/journal_articledrugselectron transportLeishmaniasismitochondriaplant-derived products |
| spellingShingle | Chandrima Shaha Plant-derived products as anti-leishmanials which target mitochondria: a review Expert Reviews in Molecular Medicine drugs electron transport Leishmaniasis mitochondria plant-derived products |
| title | Plant-derived products as anti-leishmanials which target mitochondria: a review |
| title_full | Plant-derived products as anti-leishmanials which target mitochondria: a review |
| title_fullStr | Plant-derived products as anti-leishmanials which target mitochondria: a review |
| title_full_unstemmed | Plant-derived products as anti-leishmanials which target mitochondria: a review |
| title_short | Plant-derived products as anti-leishmanials which target mitochondria: a review |
| title_sort | plant derived products as anti leishmanials which target mitochondria a review |
| topic | drugs electron transport Leishmaniasis mitochondria plant-derived products |
| url | https://www.cambridge.org/core/product/identifier/S1462399425000080/type/journal_article |
| work_keys_str_mv | AT chandrimashaha plantderivedproductsasantileishmanialswhichtargetmitochondriaareview |