HUWE1‐Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury

HUWE1‐Mediated Degradation of MUTYH Facilitates DNA Damage and Mitochondrial Dysfunction to Promote Acute Kidney Injury

Abstract The role of MUTYH, a DNA repair glycosylase in the pathogenesis of acute kidney injury (AKI) is unclear. In this study, it is found that MUTYH protein levels are significantly decreased in the kidneys of cisplatin‐ or folic acid (FA)‐induced mouse AKI models and patients with AKI. MUTYH def...

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Bibliographic Details
Main Authors: Yunwen Yang, Peipei Wang, Kaiqian Zhou, Wen Zhang, Suwen Liu, Jing Ouyang, Mi Bai, Guixia Ding, Songming Huang, Zhanjun Jia, Aihua Zhang
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
acute kidney injury
base excision repair
DNA damage
HUWE1
MUTYH
Online Access:https://doi.org/10.1002/advs.202412250
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