CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experience

Abstract Aims Cancer patients and survivors are at increased risk of developing heart failure (HF) and heart failure hospitalization (HFH). Yet, the utilization of wireless pulmonary artery pressure sensing devices (PAPSD), like CardioMEMS, in this group is limited. Objectives We aimed to explore th...

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Main Authors: Abdelrahman Ali, Maximillian Bourdillon, Hyeon-Ju Ryoo Ali, Juhee Song, Efstratios Koutroumpakis, Poonam Jewani, Shaden Khalaf, Ihab Hamzeh, Salil Kumar, Nicolas L. Palaskas, Jean-Bernard Durand, Cezar Iliescu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Cardio-Oncology
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Online Access:https://doi.org/10.1186/s40959-025-00355-0
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author Abdelrahman Ali
Maximillian Bourdillon
Hyeon-Ju Ryoo Ali
Juhee Song
Efstratios Koutroumpakis
Poonam Jewani
Shaden Khalaf
Ihab Hamzeh
Salil Kumar
Nicolas L. Palaskas
Jean-Bernard Durand
Cezar Iliescu
author_facet Abdelrahman Ali
Maximillian Bourdillon
Hyeon-Ju Ryoo Ali
Juhee Song
Efstratios Koutroumpakis
Poonam Jewani
Shaden Khalaf
Ihab Hamzeh
Salil Kumar
Nicolas L. Palaskas
Jean-Bernard Durand
Cezar Iliescu
author_sort Abdelrahman Ali
collection DOAJ
description Abstract Aims Cancer patients and survivors are at increased risk of developing heart failure (HF) and heart failure hospitalization (HFH). Yet, the utilization of wireless pulmonary artery pressure sensing devices (PAPSD), like CardioMEMS, in this group is limited. Objectives We aimed to explore the utilization of CardioMEMS in managing HF among oncology patients. Methods We conducted a single-center retrospective study reviewing consecutive patients implanted with the CardioMEMS device between November 11, 2015, and February 21, 2023. We analyzed the device's impact on pulmonary artery pressures and HFH using statistical methods including Cox regression models and correlation studies between NT-proBNP levels and hemodynamic parameters. Results The study included 28 patients, with hypertension (78%) and hyperlipidemia (78%) as prevalent comorbidities. Most patients had heart failure with preserved ejection fraction (64%). Post-implantation, we observed a reduction in HFH and improvements in pulmonary artery pressures. Cox regression identified prior HFH and elevated pulmonary artery systolic (PAS) and diastolic pressures (PAD) as risk factors for repeat HFH (HR: 1.24, 1.04, 1.07, respectively). Biomarker analysis showed a moderate positive correlation between NT-proBNP and PAD, indicating that higher levels are associated with increased hospital admissions. The device was safe with no sensor failures reported. Conclusions CardioMEMS shows potential in improving HF management in cancer patients, reducing HFH and enhancing pulmonary artery pressure profiles. These preliminary results advocate for further, larger-scale prospective studies to confirm the benefits and integrate CardioMEMS into cardio-oncology care. Graphical Abstract
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spelling doaj-art-6cce26418eff4e5badd8b131a6f459382025-08-20T03:42:03ZengBMCCardio-Oncology2057-38042025-07-0111111110.1186/s40959-025-00355-0CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experienceAbdelrahman Ali0Maximillian Bourdillon1Hyeon-Ju Ryoo Ali2Juhee Song3Efstratios Koutroumpakis4Poonam Jewani5Shaden Khalaf6Ihab Hamzeh7Salil Kumar8Nicolas L. Palaskas9Jean-Bernard Durand10Cezar Iliescu11Department of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDivision of Cardiology, Department of Internal Medicine, McGovern Medical SchoolDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Biostatistics, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterDepartment of Cardiology, Division of Internal Medicine, The University of Texas MD Anderson Cancer CenterAbstract Aims Cancer patients and survivors are at increased risk of developing heart failure (HF) and heart failure hospitalization (HFH). Yet, the utilization of wireless pulmonary artery pressure sensing devices (PAPSD), like CardioMEMS, in this group is limited. Objectives We aimed to explore the utilization of CardioMEMS in managing HF among oncology patients. Methods We conducted a single-center retrospective study reviewing consecutive patients implanted with the CardioMEMS device between November 11, 2015, and February 21, 2023. We analyzed the device's impact on pulmonary artery pressures and HFH using statistical methods including Cox regression models and correlation studies between NT-proBNP levels and hemodynamic parameters. Results The study included 28 patients, with hypertension (78%) and hyperlipidemia (78%) as prevalent comorbidities. Most patients had heart failure with preserved ejection fraction (64%). Post-implantation, we observed a reduction in HFH and improvements in pulmonary artery pressures. Cox regression identified prior HFH and elevated pulmonary artery systolic (PAS) and diastolic pressures (PAD) as risk factors for repeat HFH (HR: 1.24, 1.04, 1.07, respectively). Biomarker analysis showed a moderate positive correlation between NT-proBNP and PAD, indicating that higher levels are associated with increased hospital admissions. The device was safe with no sensor failures reported. Conclusions CardioMEMS shows potential in improving HF management in cancer patients, reducing HFH and enhancing pulmonary artery pressure profiles. These preliminary results advocate for further, larger-scale prospective studies to confirm the benefits and integrate CardioMEMS into cardio-oncology care. Graphical Abstracthttps://doi.org/10.1186/s40959-025-00355-0CardioMEMSPulmonary artery pressure sensing devicesHeart failureCardio-oncology
spellingShingle Abdelrahman Ali
Maximillian Bourdillon
Hyeon-Ju Ryoo Ali
Juhee Song
Efstratios Koutroumpakis
Poonam Jewani
Shaden Khalaf
Ihab Hamzeh
Salil Kumar
Nicolas L. Palaskas
Jean-Bernard Durand
Cezar Iliescu
CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experience
Cardio-Oncology
CardioMEMS
Pulmonary artery pressure sensing devices
Heart failure
Cardio-oncology
title CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experience
title_full CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experience
title_fullStr CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experience
title_full_unstemmed CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experience
title_short CardioMEMS guided heart failure management in cardio-oncology patients: a tertiary care cancer center experience
title_sort cardiomems guided heart failure management in cardio oncology patients a tertiary care cancer center experience
topic CardioMEMS
Pulmonary artery pressure sensing devices
Heart failure
Cardio-oncology
url https://doi.org/10.1186/s40959-025-00355-0
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