Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's disease
The aim of this study was to evaluate circulating intercellular adhesion molecule-1 (cICAM-1) in serum and in bronchoalveolar lavage (BAL), as a marker for the inflammatory process in patients with active Behçet's disease (BD). Circulating ICAM-1 was tested by an enzyme linked immuno-sorbent as...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000573 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849413266100453376 |
|---|---|
| author | A. Hamzaoui K. Hamzaoui A. Chabbou K. Ayed |
| author_facet | A. Hamzaoui K. Hamzaoui A. Chabbou K. Ayed |
| author_sort | A. Hamzaoui |
| collection | DOAJ |
| description | The aim of this study was to evaluate circulating intercellular adhesion molecule-1 (cICAM-1) in serum and in bronchoalveolar lavage (BAL), as a marker for the inflammatory process in patients with active Behçet's disease (BD). Circulating ICAM-1 was tested by an enzyme linked immuno-sorbent assay in serum and in BAL of patients with BD. These values were compared to those of patients with tuberculosis and to healthy controls. Increased levels of circulating ICAM-1 were found in serum from patients with active BD compared to healthy controls (p < 0.01). Similar levels of serum cICAM-1 were found in BD and tuberculosis. Additionally, both BD and tuberculosis patients exhibited high levels of cICAM-1 in BAL fluid, suggesting that this increase may be a result of the immune system activation in inflammatory sites. Circulating ICAM-1 seemed to have a good discriminative power in identifying active BD, being elevated in all active stages (p < 0.01) compared to remission BD stage. No differences were found in active BD patients depending upon the clinical manifestations. These results suggest that cICAM-1 may be involved in leucocyte adhesion and migration into the vessel wall of the lung. Circulating forms are derived from molecules expressed on the surface of activated cells, as a result of an inflammatory process. |
| format | Article |
| id | doaj-art-6cc34784ef5a4fc29a3b04d3f0fffbfe |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-6cc34784ef5a4fc29a3b04d3f0fffbfe2025-08-20T03:34:10ZengWileyMediators of Inflammation0962-93511466-18611995-01-014535535810.1155/S0962935195000573Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's diseaseA. Hamzaoui0K. Hamzaoui1A. Chabbou2K. Ayed3Department of Respiratory Diseases, Faculté de Médecine de Tunis, 9 rue Z. Essafi, Tunis 1007, TunisiaDepartment of Histology, Faculté de Médecine de Tunis, 9 rue Z. Essafi, Tunis 1007, TunisiaDepartment of Respiratory Diseases, Faculté de Médecine de Tunis, 9 rue Z. Essafi, Tunis 1007, TunisiaDepartment of Immunology, Faculté de Médecine de Tunis, 9 rue Z. Essafi, Tunis 1007, TunisiaThe aim of this study was to evaluate circulating intercellular adhesion molecule-1 (cICAM-1) in serum and in bronchoalveolar lavage (BAL), as a marker for the inflammatory process in patients with active Behçet's disease (BD). Circulating ICAM-1 was tested by an enzyme linked immuno-sorbent assay in serum and in BAL of patients with BD. These values were compared to those of patients with tuberculosis and to healthy controls. Increased levels of circulating ICAM-1 were found in serum from patients with active BD compared to healthy controls (p < 0.01). Similar levels of serum cICAM-1 were found in BD and tuberculosis. Additionally, both BD and tuberculosis patients exhibited high levels of cICAM-1 in BAL fluid, suggesting that this increase may be a result of the immune system activation in inflammatory sites. Circulating ICAM-1 seemed to have a good discriminative power in identifying active BD, being elevated in all active stages (p < 0.01) compared to remission BD stage. No differences were found in active BD patients depending upon the clinical manifestations. These results suggest that cICAM-1 may be involved in leucocyte adhesion and migration into the vessel wall of the lung. Circulating forms are derived from molecules expressed on the surface of activated cells, as a result of an inflammatory process.http://dx.doi.org/10.1155/S0962935195000573 |
| spellingShingle | A. Hamzaoui K. Hamzaoui A. Chabbou K. Ayed Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's disease Mediators of Inflammation |
| title | Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's disease |
| title_full | Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's disease |
| title_fullStr | Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's disease |
| title_full_unstemmed | Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's disease |
| title_short | Circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in Behçet's disease |
| title_sort | circulating intercellular adhesion molecules in blood and bronchoalveolar lavage in behcet s disease |
| url | http://dx.doi.org/10.1155/S0962935195000573 |
| work_keys_str_mv | AT ahamzaoui circulatingintercellularadhesionmoleculesinbloodandbronchoalveolarlavageinbehcetsdisease AT khamzaoui circulatingintercellularadhesionmoleculesinbloodandbronchoalveolarlavageinbehcetsdisease AT achabbou circulatingintercellularadhesionmoleculesinbloodandbronchoalveolarlavageinbehcetsdisease AT kayed circulatingintercellularadhesionmoleculesinbloodandbronchoalveolarlavageinbehcetsdisease |