Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults
Aim: bring to the attention of practitioners indications for anti-Helicobacter therapy, methods and procedure for diagnostics and eradication therapy of Н. pylori infection.Key points. Chronic gastritis caused by Н. pylori infection, including asymptomatic persons, may be considered as an indication...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2023-05-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/848 |
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| author | V. T. Ivashkin T. L. Lapina I. V. Maev O. M. Drapkina R. S. Kozlov A. A. Sheptulin A. S. Trukhmanov S. R. Abdulkhakov O. P. Alekseeva S. A. Alekseenko D. N. Andreev D. S. Bordin N. N. Dekhnich I. L. Klyaritskaya N. V. Korochanskaya M. F. Osipenko E. A. Poluektova A. S. Sarsenbaeva V. I. Simanenkov A. V. Tkachev A. I. Ulyanin I. B. Khlynov V. V. Tsukanov |
| author_facet | V. T. Ivashkin T. L. Lapina I. V. Maev O. M. Drapkina R. S. Kozlov A. A. Sheptulin A. S. Trukhmanov S. R. Abdulkhakov O. P. Alekseeva S. A. Alekseenko D. N. Andreev D. S. Bordin N. N. Dekhnich I. L. Klyaritskaya N. V. Korochanskaya M. F. Osipenko E. A. Poluektova A. S. Sarsenbaeva V. I. Simanenkov A. V. Tkachev A. I. Ulyanin I. B. Khlynov V. V. Tsukanov |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Aim: bring to the attention of practitioners indications for anti-Helicobacter therapy, methods and procedure for diagnostics and eradication therapy of Н. pylori infection.Key points. Chronic gastritis caused by Н. pylori infection, including asymptomatic persons, may be considered as an indication for eradication therapy of Н. pylori as etiological therapy and opportunistic screening for gastric cancer prevention. Indications, for obligatory anti-Helicobacter therapy include peptic ulcer, gastric MALT lymphoma, early gastric cancer (EGC) with endoscopic resection. H. pylori primary diagnostics methods include 13C-urea breath test, H. pylori stool antigen lab test, rapid urease test and serological method. The serological method cannot be used after anti-Helicobacter therapy.In Russia H. pylori strains' resistance to clarithromycin does not exceed 15 % in most regional studies. The first line therapy for Н. pylori infection eradication is the standard triple therapy including a proton pump inhibitor (PPI), clarithromycin and amoxicillin, enhanced with bismuthate tripotassium dicitrate. A classic four-component therapy based on bismuthate tripotassium dicitrate or quadrotherapy without bismuth drug products which includes PPI, amoxicillin, clarithromycin and metronidazole, may be used as alternative to the first line eradication therapy. The standard triple therapy may be prescribed for 14 days only in those regions, where it has been proven to be effective. Quadrotherapy with bismuthate tripotassium dicitrate is also used as main second line therapy in case of standard triple therapy, bismuth enhanced standard triple therapy or combined therapy failure. Another second line therapy includes PPI, levofloxacin and amoxicillin, to which a bismuth-containing drug product may be added. The third line therapy is selected individually based on previously used treatment settings.Conclusion. In each case of H. pylori infection the decision for eradication therapy should be made, which is especially relevant as eradication of H. pylori has been recognized as an effective measure for the prevention of gastric cancer. |
| format | Article |
| id | doaj-art-6cc32fbd92d34f03bb7aa8dcdf71d2dd |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2023-05-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-6cc32fbd92d34f03bb7aa8dcdf71d2dd2025-02-10T16:14:37ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-05-01326729310.22416/1382-4376-2022-32-6-72-93532Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in AdultsV. T. Ivashkin0T. L. Lapina1I. V. Maev2O. M. Drapkina3R. S. Kozlov4A. A. Sheptulin5A. S. Trukhmanov6S. R. Abdulkhakov7O. P. Alekseeva8S. A. Alekseenko9D. N. Andreev10D. S. Bordin11N. N. Dekhnich12I. L. Klyaritskaya13N. V. Korochanskaya14M. F. Osipenko15E. A. Poluektova16A. S. Sarsenbaeva17V. I. Simanenkov18A. V. Tkachev19A. I. Ulyanin20I. B. Khlynov21V. V. Tsukanov22Sechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversityEndocrinology Research CentreNational Research Center for Preventive MedicineSmolensk State Medical UniversitySechenov First Moscow State Medical UniversitySechenov First Moscow State Medical UniversityKazan Federal University; Kazan State Medical UniversityPrivolzhsky Research Medical UniversityFar-Eastern State Medical UniversityEndocrinology Research CentreEndocrinology Research Centre; Loginov Moscow Clinical Scientific Center; Tver State Medical UniversitySmolensk State Medical UniversityVernadsky Crimean Federal UniversityKuban State Medical UniversityNovosibirsk State Medical UniversitySechenov First Moscow State Medical UniversitySouth Ural State Medical UniversityMechnikov North-Western State Medical UniversityRostov State Medical UniversitySechenov First Moscow State Medical UniversityUral State Medical UniversityResearch Institute for Medical Problems in the North - Division of Krasnoyarsk Scientific Centre of Siberian Branch of the RASAim: bring to the attention of practitioners indications for anti-Helicobacter therapy, methods and procedure for diagnostics and eradication therapy of Н. pylori infection.Key points. Chronic gastritis caused by Н. pylori infection, including asymptomatic persons, may be considered as an indication for eradication therapy of Н. pylori as etiological therapy and opportunistic screening for gastric cancer prevention. Indications, for obligatory anti-Helicobacter therapy include peptic ulcer, gastric MALT lymphoma, early gastric cancer (EGC) with endoscopic resection. H. pylori primary diagnostics methods include 13C-urea breath test, H. pylori stool antigen lab test, rapid urease test and serological method. The serological method cannot be used after anti-Helicobacter therapy.In Russia H. pylori strains' resistance to clarithromycin does not exceed 15 % in most regional studies. The first line therapy for Н. pylori infection eradication is the standard triple therapy including a proton pump inhibitor (PPI), clarithromycin and amoxicillin, enhanced with bismuthate tripotassium dicitrate. A classic four-component therapy based on bismuthate tripotassium dicitrate or quadrotherapy without bismuth drug products which includes PPI, amoxicillin, clarithromycin and metronidazole, may be used as alternative to the first line eradication therapy. The standard triple therapy may be prescribed for 14 days only in those regions, where it has been proven to be effective. Quadrotherapy with bismuthate tripotassium dicitrate is also used as main second line therapy in case of standard triple therapy, bismuth enhanced standard triple therapy or combined therapy failure. Another second line therapy includes PPI, levofloxacin and amoxicillin, to which a bismuth-containing drug product may be added. The third line therapy is selected individually based on previously used treatment settings.Conclusion. In each case of H. pylori infection the decision for eradication therapy should be made, which is especially relevant as eradication of H. pylori has been recognized as an effective measure for the prevention of gastric cancer.https://www.gastro-j.ru/jour/article/view/848<i>helicobacter pylori</i>chronic gastritisgastric malt lymphoma<i>h. pylori</i> eradication therapy<sup>13</sup>c-urea breath testrapid urease test |
| spellingShingle | V. T. Ivashkin T. L. Lapina I. V. Maev O. M. Drapkina R. S. Kozlov A. A. Sheptulin A. S. Trukhmanov S. R. Abdulkhakov O. P. Alekseeva S. A. Alekseenko D. N. Andreev D. S. Bordin N. N. Dekhnich I. L. Klyaritskaya N. V. Korochanskaya M. F. Osipenko E. A. Poluektova A. S. Sarsenbaeva V. I. Simanenkov A. V. Tkachev A. I. Ulyanin I. B. Khlynov V. V. Tsukanov Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults Российский журнал гастроэнтерологии, гепатологии, колопроктологии <i>helicobacter pylori</i> chronic gastritis gastric malt lymphoma <i>h. pylori</i> eradication therapy <sup>13</sup>c-urea breath test rapid urease test |
| title | Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults |
| title_full | Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults |
| title_fullStr | Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults |
| title_full_unstemmed | Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults |
| title_short | Clinical Practice Guidelines of Russian Gastroenterological Association, Scientific Society for the Clinical Study of Human Microbiome, Russian Society for the Prevention of Non-Communicable Diseases, Interregional Association for Clinical Microbiology and Antimicrobial Chemotherapy for <i>H. pylori</i> Diagnostics and Treatment in Adults |
| title_sort | clinical practice guidelines of russian gastroenterological association scientific society for the clinical study of human microbiome russian society for the prevention of non communicable diseases interregional association for clinical microbiology and antimicrobial chemotherapy for i h pylori i diagnostics and treatment in adults |
| topic | <i>helicobacter pylori</i> chronic gastritis gastric malt lymphoma <i>h. pylori</i> eradication therapy <sup>13</sup>c-urea breath test rapid urease test |
| url | https://www.gastro-j.ru/jour/article/view/848 |
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