Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia
Abstract Objective Anaplastic large cell lymphoma (ALCL) is a rare and aggressive CD30-positive non-Hodgkin lymphoma with histopathological features overlapping Hodgkin and T-cell lymphomas. ALK-positive ALCL shows a better prognosis than ALK-negative cases, which are often associated with advanced...
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| Language: | English |
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BMC
2025-07-01
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| Series: | BMC Research Notes |
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| Online Access: | https://doi.org/10.1186/s13104-025-07354-5 |
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| author | Agnes Stephanie Harahap Ivana Santoso Stefanny Charles Nadia Ayu Mulansari Maria Francisca Ham |
| author_facet | Agnes Stephanie Harahap Ivana Santoso Stefanny Charles Nadia Ayu Mulansari Maria Francisca Ham |
| author_sort | Agnes Stephanie Harahap |
| collection | DOAJ |
| description | Abstract Objective Anaplastic large cell lymphoma (ALCL) is a rare and aggressive CD30-positive non-Hodgkin lymphoma with histopathological features overlapping Hodgkin and T-cell lymphomas. ALK-positive ALCL shows a better prognosis than ALK-negative cases, which are often associated with advanced disease. This study evaluates the epidemiological profile of ALCL in Indonesian population and its distinct histopathological characteristics and immunohistochemical expression patterns. Results Among 93 ALCL cases (2013–2023) enrolled at Dr. Cipto Mangunkusumo Hospital, 13.9% were primary cutaneous ALCL, while 86.1% were systemic ALCL (consisted of 53.7% ALK-positive and 46.3% ALK-negative). ALK-positive patients were older (p = 0.009), with earlier-stage disease (p = 0.032) and nodal predilection (p = 0.032). ALK-negative cases demonstrated a shorter median survival of 23 months compared to ALK-positive cases of 28 months. Poor outcomes were associated with B symptoms and high Eastern Cooperative Oncology Group Performance Status (ECOG-PS) scores. Given that this study was conducted at a single, government-operated tertiary care teaching hospital in Indonesia’s capital, validation through multicenter prospective studies is warranted to further refine diagnostic and therapeutic strategies. |
| format | Article |
| id | doaj-art-6cc1c80b06284f42bbdb681d9beb7ce4 |
| institution | Kabale University |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj-art-6cc1c80b06284f42bbdb681d9beb7ce42025-08-20T04:01:44ZengBMCBMC Research Notes1756-05002025-07-011811910.1186/s13104-025-07354-5Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from IndonesiaAgnes Stephanie Harahap0Ivana Santoso1Stefanny Charles2Nadia Ayu Mulansari3Maria Francisca Ham4Anatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General HospitalHuman Cancer Research Center-Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas IndonesiaHuman Cancer Research Center-Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas IndonesiaHematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General HospitalAnatomical Pathology Department, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo National Central General HospitalAbstract Objective Anaplastic large cell lymphoma (ALCL) is a rare and aggressive CD30-positive non-Hodgkin lymphoma with histopathological features overlapping Hodgkin and T-cell lymphomas. ALK-positive ALCL shows a better prognosis than ALK-negative cases, which are often associated with advanced disease. This study evaluates the epidemiological profile of ALCL in Indonesian population and its distinct histopathological characteristics and immunohistochemical expression patterns. Results Among 93 ALCL cases (2013–2023) enrolled at Dr. Cipto Mangunkusumo Hospital, 13.9% were primary cutaneous ALCL, while 86.1% were systemic ALCL (consisted of 53.7% ALK-positive and 46.3% ALK-negative). ALK-positive patients were older (p = 0.009), with earlier-stage disease (p = 0.032) and nodal predilection (p = 0.032). ALK-negative cases demonstrated a shorter median survival of 23 months compared to ALK-positive cases of 28 months. Poor outcomes were associated with B symptoms and high Eastern Cooperative Oncology Group Performance Status (ECOG-PS) scores. Given that this study was conducted at a single, government-operated tertiary care teaching hospital in Indonesia’s capital, validation through multicenter prospective studies is warranted to further refine diagnostic and therapeutic strategies.https://doi.org/10.1186/s13104-025-07354-5Anaplastic large cell lymphomaALK-positive ALCLALK-negative ALCLClinicopathologic characteristicsImmunohistochemistryPrognostic factors |
| spellingShingle | Agnes Stephanie Harahap Ivana Santoso Stefanny Charles Nadia Ayu Mulansari Maria Francisca Ham Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia BMC Research Notes Anaplastic large cell lymphoma ALK-positive ALCL ALK-negative ALCL Clinicopathologic characteristics Immunohistochemistry Prognostic factors |
| title | Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia |
| title_full | Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia |
| title_fullStr | Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia |
| title_full_unstemmed | Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia |
| title_short | Comprehensive study of anaplastic large cell lymphoma: clinicopathological features from Indonesia |
| title_sort | comprehensive study of anaplastic large cell lymphoma clinicopathological features from indonesia |
| topic | Anaplastic large cell lymphoma ALK-positive ALCL ALK-negative ALCL Clinicopathologic characteristics Immunohistochemistry Prognostic factors |
| url | https://doi.org/10.1186/s13104-025-07354-5 |
| work_keys_str_mv | AT agnesstephanieharahap comprehensivestudyofanaplasticlargecelllymphomaclinicopathologicalfeaturesfromindonesia AT ivanasantoso comprehensivestudyofanaplasticlargecelllymphomaclinicopathologicalfeaturesfromindonesia AT stefannycharles comprehensivestudyofanaplasticlargecelllymphomaclinicopathologicalfeaturesfromindonesia AT nadiaayumulansari comprehensivestudyofanaplasticlargecelllymphomaclinicopathologicalfeaturesfromindonesia AT mariafranciscaham comprehensivestudyofanaplasticlargecelllymphomaclinicopathologicalfeaturesfromindonesia |