Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine
The organ-on-a-chip (OoC) technology holds significant promise for biosensors and personalized medicine by enabling the creation of miniature, patient-specific models of human organs. This review studies the recent advancements in the application of polydimethylsiloxane (PDMS) microfluidics for OoC...
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| Format: | Article |
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MDPI AG
2025-01-01
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| Series: | Biosensors |
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| Online Access: | https://www.mdpi.com/2079-6374/15/2/76 |
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| author | Fahad Alghannam Mrwan Alayed Salman Alfihed Mahmoud A. Sakr Dhaifallah Almutairi Naif Alshamrani Nojoud Al Fayez |
| author_facet | Fahad Alghannam Mrwan Alayed Salman Alfihed Mahmoud A. Sakr Dhaifallah Almutairi Naif Alshamrani Nojoud Al Fayez |
| author_sort | Fahad Alghannam |
| collection | DOAJ |
| description | The organ-on-a-chip (OoC) technology holds significant promise for biosensors and personalized medicine by enabling the creation of miniature, patient-specific models of human organs. This review studies the recent advancements in the application of polydimethylsiloxane (PDMS) microfluidics for OoC purposes. It underscores the main fabrication technologies of PDMS microfluidic systems, such as photolithography, injection molding, hot embossing, and 3D printing. The review also highlights the crucial role of integrated biosensors within OoC platforms. These electrochemical, electrical, and optical sensors, integrated within the microfluidic environment, provide valuable insights into cellular behavior and drug response. Furthermore, the review explores the exciting potential of PDMS-based OoC technology for personalized medicine. OoC devices can forecast drug effectiveness and tailor therapeutic strategies for patients by incorporating patient-derived cells and replicating individual physiological variations, helping the healing process and accelerating recovery. This personalized approach can revolutionize healthcare by offering more precise and efficient treatment options. Understanding OoC fabrication and its applications in biosensors and personalized medicine can play a pivotal role in future implementations of multifunctional OoC biosensors. |
| format | Article |
| id | doaj-art-6cba48e8fb494cf381f7d60b7fcd7649 |
| institution | DOAJ |
| issn | 2079-6374 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biosensors |
| spelling | doaj-art-6cba48e8fb494cf381f7d60b7fcd76492025-08-20T02:44:52ZengMDPI AGBiosensors2079-63742025-01-011527610.3390/bios15020076Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized MedicineFahad Alghannam0Mrwan Alayed1Salman Alfihed2Mahmoud A. Sakr3Dhaifallah Almutairi4Naif Alshamrani5Nojoud Al Fayez6Microelectronics and Semiconductors Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaMicroelectronics and Semiconductors Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaMicroelectronics and Semiconductors Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaDonnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON M5S 3E1, CanadaMicroelectronics and Semiconductors Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaMicroelectronics and Semiconductors Institute, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaAdvanced Diagnostics and Therapeutics Institute, Health Sector, King Abdulaziz City for Science and Technology (KACST), Riyadh 12354, Saudi ArabiaThe organ-on-a-chip (OoC) technology holds significant promise for biosensors and personalized medicine by enabling the creation of miniature, patient-specific models of human organs. This review studies the recent advancements in the application of polydimethylsiloxane (PDMS) microfluidics for OoC purposes. It underscores the main fabrication technologies of PDMS microfluidic systems, such as photolithography, injection molding, hot embossing, and 3D printing. The review also highlights the crucial role of integrated biosensors within OoC platforms. These electrochemical, electrical, and optical sensors, integrated within the microfluidic environment, provide valuable insights into cellular behavior and drug response. Furthermore, the review explores the exciting potential of PDMS-based OoC technology for personalized medicine. OoC devices can forecast drug effectiveness and tailor therapeutic strategies for patients by incorporating patient-derived cells and replicating individual physiological variations, helping the healing process and accelerating recovery. This personalized approach can revolutionize healthcare by offering more precise and efficient treatment options. Understanding OoC fabrication and its applications in biosensors and personalized medicine can play a pivotal role in future implementations of multifunctional OoC biosensors.https://www.mdpi.com/2079-6374/15/2/76microfluidicsorgan-on-a-chip (OoC)PDMSintegrationbiosensorspersonalized medicine |
| spellingShingle | Fahad Alghannam Mrwan Alayed Salman Alfihed Mahmoud A. Sakr Dhaifallah Almutairi Naif Alshamrani Nojoud Al Fayez Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine Biosensors microfluidics organ-on-a-chip (OoC) PDMS integration biosensors personalized medicine |
| title | Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine |
| title_full | Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine |
| title_fullStr | Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine |
| title_full_unstemmed | Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine |
| title_short | Recent Progress in PDMS-Based Microfluidics Toward Integrated Organ-on-a-Chip Biosensors and Personalized Medicine |
| title_sort | recent progress in pdms based microfluidics toward integrated organ on a chip biosensors and personalized medicine |
| topic | microfluidics organ-on-a-chip (OoC) PDMS integration biosensors personalized medicine |
| url | https://www.mdpi.com/2079-6374/15/2/76 |
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