Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions
Adhesions are the body’s natural response to various inflammatory causes, with surgery being the most common cause. However, the formation of postoperative adhesions can lead to significant complications, including intestinal obstruction and chronic pain. To prevent such postoperative complications...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-03-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/17/3/389 |
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| author | Zi Yi Teo Samyuktha Dhanalakshmi Senthilkumar Dinesh Kumar Srinivasan |
| author_facet | Zi Yi Teo Samyuktha Dhanalakshmi Senthilkumar Dinesh Kumar Srinivasan |
| author_sort | Zi Yi Teo |
| collection | DOAJ |
| description | Adhesions are the body’s natural response to various inflammatory causes, with surgery being the most common cause. However, the formation of postoperative adhesions can lead to significant complications, including intestinal obstruction and chronic pain. To prevent such postoperative complications associated with adhesions, developing effective strategies for adhesion prevention has been a major focus of research. Currently, several therapeutic models have been developed to achieve this objective. These include pharmaceuticals, inert polymers, functional biomaterials, and nanotherapeutics. Among the various strategies developed, nanotherapeutics, though still in its early stages, has shown promise as a potential approach. Other therapeutic models are associated with adverse side effects and complications related to their application. On the other hand, nanotherapeutic models are able to overcome the limitations of the other strategies and provide their own set of unique advantages. Hence, nanotherapeutics represents a promising area for further research. Further efforts should be made to refine existing nanotherapeutics for clinical application while also addressing associated safety and ethical concerns related to their use in medical practice. Therefore, this article aims to review the various nanotherapeutic approaches developed for the prevention of postoperative adhesions, explore their regulatory pathways, and discuss associated safety and ethical concerns. |
| format | Article |
| id | doaj-art-6cb4b3c2f4434c3184fef91b5e2737a5 |
| institution | Kabale University |
| issn | 1999-4923 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj-art-6cb4b3c2f4434c3184fef91b5e2737a52025-08-20T03:43:40ZengMDPI AGPharmaceutics1999-49232025-03-0117338910.3390/pharmaceutics17030389Nanotechnology-Based Therapies for Preventing Post-Surgical AdhesionsZi Yi Teo0Samyuktha Dhanalakshmi Senthilkumar1Dinesh Kumar Srinivasan2Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeYong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, SingaporeDepartment of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, SingaporeAdhesions are the body’s natural response to various inflammatory causes, with surgery being the most common cause. However, the formation of postoperative adhesions can lead to significant complications, including intestinal obstruction and chronic pain. To prevent such postoperative complications associated with adhesions, developing effective strategies for adhesion prevention has been a major focus of research. Currently, several therapeutic models have been developed to achieve this objective. These include pharmaceuticals, inert polymers, functional biomaterials, and nanotherapeutics. Among the various strategies developed, nanotherapeutics, though still in its early stages, has shown promise as a potential approach. Other therapeutic models are associated with adverse side effects and complications related to their application. On the other hand, nanotherapeutic models are able to overcome the limitations of the other strategies and provide their own set of unique advantages. Hence, nanotherapeutics represents a promising area for further research. Further efforts should be made to refine existing nanotherapeutics for clinical application while also addressing associated safety and ethical concerns related to their use in medical practice. Therefore, this article aims to review the various nanotherapeutic approaches developed for the prevention of postoperative adhesions, explore their regulatory pathways, and discuss associated safety and ethical concerns.https://www.mdpi.com/1999-4923/17/3/389adhesionpost-operationnanotherapeuticsnanocompositeshydrogelsnanofibers |
| spellingShingle | Zi Yi Teo Samyuktha Dhanalakshmi Senthilkumar Dinesh Kumar Srinivasan Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions Pharmaceutics adhesion post-operation nanotherapeutics nanocomposites hydrogels nanofibers |
| title | Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions |
| title_full | Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions |
| title_fullStr | Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions |
| title_full_unstemmed | Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions |
| title_short | Nanotechnology-Based Therapies for Preventing Post-Surgical Adhesions |
| title_sort | nanotechnology based therapies for preventing post surgical adhesions |
| topic | adhesion post-operation nanotherapeutics nanocomposites hydrogels nanofibers |
| url | https://www.mdpi.com/1999-4923/17/3/389 |
| work_keys_str_mv | AT ziyiteo nanotechnologybasedtherapiesforpreventingpostsurgicaladhesions AT samyukthadhanalakshmisenthilkumar nanotechnologybasedtherapiesforpreventingpostsurgicaladhesions AT dineshkumarsrinivasan nanotechnologybasedtherapiesforpreventingpostsurgicaladhesions |