Acute Sympathetic Blockade Improves Insulin‐Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity

Acute Sympathetic Blockade Improves Insulin‐Mediated Microvascular Blood Flow in the Forearm of Adult Human Subjects With Obesity

Background Obesity is associated with resistance to the metabolic (glucose uptake) and vascular (nitric‐oxide mediated dilation and microvascular recruitment) actions of insulin. These vascular effects contribute to insulin sensitivity by increasing tissue delivery of glucose. Studies by us and othe...

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Bibliographic Details
Main Authors: Emily C. Smith, Jay N. Patel, Amr Wahba, Andrew Cluckey, Jorge Celedonio, JinWoo Park, LaToya Hannah, Suzanna Lonce, Cyndya A. Shibao, Sachin Y. Paranjape, Andre Diedrich, Owen McGuinness, David H. Wasserman, Italo Biaggioni, Alfredo Gamboa
Format: Article
Language:English
Published: Wiley 2024-08-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
autonomic nervous system
insulin resistance
microvascular
obesity
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.030775
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