Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions
Polycystic ovary syndrome (PCOS) is the expression of a complex alteration of the reproductive system. It is characterised by the increase in androgens, causing symptoms such as hirsutism, as well as infertility in many. This paper reviews whether Clomiphene Citrate, Letrozole and Inositol function...
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MDPI AG
2025-05-01
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| author | Alessia Mahoney Arianna D’Angelo |
| author_facet | Alessia Mahoney Arianna D’Angelo |
| author_sort | Alessia Mahoney |
| collection | DOAJ |
| description | Polycystic ovary syndrome (PCOS) is the expression of a complex alteration of the reproductive system. It is characterised by the increase in androgens, causing symptoms such as hirsutism, as well as infertility in many. This paper reviews whether Clomiphene Citrate, Letrozole and Inositol function better as monotherapy or combined therapy for anovulatory infertile PCOS patients. Ovulation and pregnancy rate were used as primary outcomes. PubMed and Scopus were the search engines of choice. Papers were excluded if patients were undertaking other fertility interventions, overlapping populations and non-RCT papers. It was found that co-prescribing Letrozole or Clomiphene Citrate alongside Metformin should be considered, Inositol should be examined as an alternative insulin sensitiser to Metformin and studies should be undertaken to identify the ideal dose and duration of Inositol therapy. Further large, well-designed, multi-centre studies should be conducted to solidify the claims of this review. |
| format | Article |
| id | doaj-art-6cb1017f157f4489beeed83bf469fd0f |
| institution | OA Journals |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-6cb1017f157f4489beeed83bf469fd0f2025-08-20T02:21:03ZengMDPI AGLife2075-17292025-05-0115686310.3390/life15060863Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future DirectionsAlessia Mahoney0Arianna D’Angelo1School of Medicine, Cardiff University, Cardiff CF14 4YS, UKSchool of Medicine, Cardiff University, Cardiff CF14 4YS, UKPolycystic ovary syndrome (PCOS) is the expression of a complex alteration of the reproductive system. It is characterised by the increase in androgens, causing symptoms such as hirsutism, as well as infertility in many. This paper reviews whether Clomiphene Citrate, Letrozole and Inositol function better as monotherapy or combined therapy for anovulatory infertile PCOS patients. Ovulation and pregnancy rate were used as primary outcomes. PubMed and Scopus were the search engines of choice. Papers were excluded if patients were undertaking other fertility interventions, overlapping populations and non-RCT papers. It was found that co-prescribing Letrozole or Clomiphene Citrate alongside Metformin should be considered, Inositol should be examined as an alternative insulin sensitiser to Metformin and studies should be undertaken to identify the ideal dose and duration of Inositol therapy. Further large, well-designed, multi-centre studies should be conducted to solidify the claims of this review.https://www.mdpi.com/2075-1729/15/6/863fertilityPCOSanovulationclomiphene citrateletrozolemyo-Inositol |
| spellingShingle | Alessia Mahoney Arianna D’Angelo Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions Life fertility PCOS anovulation clomiphene citrate letrozole myo-Inositol |
| title | Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions |
| title_full | Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions |
| title_fullStr | Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions |
| title_full_unstemmed | Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions |
| title_short | Treatment Options for Managing Anovulation in Women with PCOS: An Extensive Literature Review of Evidence-Based Recommendations for Future Directions |
| title_sort | treatment options for managing anovulation in women with pcos an extensive literature review of evidence based recommendations for future directions |
| topic | fertility PCOS anovulation clomiphene citrate letrozole myo-Inositol |
| url | https://www.mdpi.com/2075-1729/15/6/863 |
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