Tumor-intrinsic interferon signaling drives pancreatic cancer resistance to tumor mucin1-targeted CAR T cell therapy

Tumor-intrinsic interferon signaling drives pancreatic cancer resistance to tumor mucin1-targeted CAR T cell therapy

Pancreatic cancer (PC) remains one of the most challenging cancers and has the worst prognosis. Tumor-associated MUC1 (tMUC1) is overexpressed and aberrantly glycosylated in over 80% of human pancreatic ductal adenocarcinoma (PDA). Chimeric antigen receptor (CAR) engineered T cells are an emerging c...

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Bibliographic Details
Main Authors: Ru Zhou, Rebecca Mayberry, Taina Firmin, Alexa Sanders, Cory Brouwer, John Maher, Pinku Mukherjee
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
CAR T cells
MUC1
PDA
resistance
interferon signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1618415/full
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