Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease
Pemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/5980937 |
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| author | Thanisorn Sukakul Supenya Varothai |
| author_facet | Thanisorn Sukakul Supenya Varothai |
| author_sort | Thanisorn Sukakul |
| collection | DOAJ |
| description | Pemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that misled the diagnosis for months. The final diagnosis of Hallopeau-type pemphigus vegetans was made based on histopathology and direct immunofluorescence studies. Interestingly, not only the clinical presentation was atypical, but blood tests for anti-desmoglein 1 and 3 antibodies by ELISA technique were also negative. Thus, the rare unusual manifestation of pemphigus vegetans in this patient may associate with different autoantibodies to desmosomal proteins compared with those of classic pemphigus patients. |
| format | Article |
| id | doaj-art-6ca38650712d491c9f2f30aa9ceb61fb |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-6ca38650712d491c9f2f30aa9ceb61fb2025-08-20T03:34:09ZengWileyCase Reports in Medicine1687-96271687-96352018-01-01201810.1155/2018/59809375980937Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune DiseaseThanisorn Sukakul0Supenya Varothai1Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandDepartment of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, ThailandPemphigus vegetans is a rare variant of deep acantholytic pemphigus which usually presents with vesiculobullous rash and vegetative plaques on the folds. We report a case of pemphigus vegetans patient who presented with rashes on tips of fingers and toes resembling paronychia and onychomadesis that misled the diagnosis for months. The final diagnosis of Hallopeau-type pemphigus vegetans was made based on histopathology and direct immunofluorescence studies. Interestingly, not only the clinical presentation was atypical, but blood tests for anti-desmoglein 1 and 3 antibodies by ELISA technique were also negative. Thus, the rare unusual manifestation of pemphigus vegetans in this patient may associate with different autoantibodies to desmosomal proteins compared with those of classic pemphigus patients.http://dx.doi.org/10.1155/2018/5980937 |
| spellingShingle | Thanisorn Sukakul Supenya Varothai Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease Case Reports in Medicine |
| title | Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease |
| title_full | Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease |
| title_fullStr | Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease |
| title_full_unstemmed | Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease |
| title_short | Chronic Paronychia and Onychomadesis in Pemphigus Vegetans: An Unusual Presentation in a Rare Autoimmune Disease |
| title_sort | chronic paronychia and onychomadesis in pemphigus vegetans an unusual presentation in a rare autoimmune disease |
| url | http://dx.doi.org/10.1155/2018/5980937 |
| work_keys_str_mv | AT thanisornsukakul chronicparonychiaandonychomadesisinpemphigusvegetansanunusualpresentationinarareautoimmunedisease AT supenyavarothai chronicparonychiaandonychomadesisinpemphigusvegetansanunusualpresentationinarareautoimmunedisease |