TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model

TAT-CRE inhalation enables tumor induction corresponding to adenoviral Cre-recombinase in a lung cancer mouse model

Abstract Cre-recombinase inducible model systems are extensively used in cancer research to manipulate gene expression in specific tissues and induce autochthonous tumor growth. These systems often involve the cross-breeding of genetically engineered organisms containing loxP-flanked alleles with th...

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Main Authors: Tabea Gewalt, Anna M. Dmitrieva, Felix Elsner, Xinlei Zhao, Daniel Dimitri Sieber, Ilayda Gülsen Kocak, Qian Yang, Claudia Viktoria Orschel, Naja Maria Eckert, Bianca Goebel, Marieke Nill, Franziska Peter, Arndt Hartmann, Filippo Beleggia, Margarete Odenthal, Hans Christian Reinhardt, Roland Tillmann Ullrich, Frederik Graw, Lydia Meder
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-08146-0
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