Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan
Background. The major candidate genes for ovarian cancer (BRCA1/2) explain no more than 15–20 % of cases; therefore it is important to focus on the search for new molecular genetic markers. The aim of the study was to analyze the association of rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2025-03-01
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| Series: | Сибирский онкологический журнал |
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| Online Access: | https://www.siboncoj.ru/jour/article/view/3465 |
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| author | E. A. Andreeva E. T. Aminova R. R. Faiskhanova I. R. Zagitov Y. V. Valova Yu. Yu. Fedorova A. Kh. Nurgalieva M. Darvish D. D. Sakaeva E. K. Khusnutdinova D. S. Prokofyeva |
| author_facet | E. A. Andreeva E. T. Aminova R. R. Faiskhanova I. R. Zagitov Y. V. Valova Yu. Yu. Fedorova A. Kh. Nurgalieva M. Darvish D. D. Sakaeva E. K. Khusnutdinova D. S. Prokofyeva |
| author_sort | E. A. Andreeva |
| collection | DOAJ |
| description | Background. The major candidate genes for ovarian cancer (BRCA1/2) explain no more than 15–20 % of cases; therefore it is important to focus on the search for new molecular genetic markers. The aim of the study was to analyze the association of rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA polymorphic variants with the risk of developing ovarian cancer in women from the Republic of Bashkortostan. Material and methods. Our research included DNA samples of women with ovarian cancer (n=205) and women without cancer at the time of blood sampling (n=259) from the Republic of Bashkortostan. Genotyping was carried out using the Real Time PCR method based on TaqMan technology. Results. Polymorphic variants, such as rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA were not associated with the risk of developing ovarian cancer in women of the Republic of Bashkortostan. However, the rs11549465/HIF1A polymorphic locus was significantly correlated with the grade of tumor cell differentiation, and the rs3025039/VEGFA was associated with lymph node metastasis. Conclusion. These polymorphic variants may be associated with ovarian cancer prognosis. to confirm this association, it is necessary to conduct research on a large sample size. |
| format | Article |
| id | doaj-art-6ca14e79137f4d5e98ea55dc2cfa15f4 |
| institution | Kabale University |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| publishDate | 2025-03-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj-art-6ca14e79137f4d5e98ea55dc2cfa15f42025-08-20T03:43:40ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682025-03-01241799110.21294/1814-4861-2025-24-1-79-911325Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from BashkortostanE. A. Andreeva0E. T. Aminova1R. R. Faiskhanova2I. R. Zagitov3Y. V. Valova4Yu. Yu. Fedorova5A. Kh. Nurgalieva6M. Darvish7D. D. Sakaeva8E. K. Khusnutdinova9D. S. Prokofyeva10Ufa State University of Science and Technology; Ural Medical InstituteUfa State University of Science and TechnologyRepublican Clinical Oncology DispensaryRepublican Clinical Oncology DispensaryUfa State University of Science and Technology; Ufa Research Institute of Occupational Health and Human EcologyUfa State University of Science and TechnologyUfa State University of Science and TechnologyArak University of Medical Sciences, School of MedicineBashkir State Medical UniversityUfa State University of Science and Technology; Bashkir State Medical University; Institute of Biochemistry and Genetics, Ufa Scientific Center, Russian Academy of SciencesUfa State University of Science and TechnologyBackground. The major candidate genes for ovarian cancer (BRCA1/2) explain no more than 15–20 % of cases; therefore it is important to focus on the search for new molecular genetic markers. The aim of the study was to analyze the association of rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA polymorphic variants with the risk of developing ovarian cancer in women from the Republic of Bashkortostan. Material and methods. Our research included DNA samples of women with ovarian cancer (n=205) and women without cancer at the time of blood sampling (n=259) from the Republic of Bashkortostan. Genotyping was carried out using the Real Time PCR method based on TaqMan technology. Results. Polymorphic variants, such as rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA were not associated with the risk of developing ovarian cancer in women of the Republic of Bashkortostan. However, the rs11549465/HIF1A polymorphic locus was significantly correlated with the grade of tumor cell differentiation, and the rs3025039/VEGFA was associated with lymph node metastasis. Conclusion. These polymorphic variants may be associated with ovarian cancer prognosis. to confirm this association, it is necessary to conduct research on a large sample size.https://www.siboncoj.ru/jour/article/view/3465ovarian cancermolecular genetic researchassociative analysisgenetic polymorphismshif 1avegf |
| spellingShingle | E. A. Andreeva E. T. Aminova R. R. Faiskhanova I. R. Zagitov Y. V. Valova Yu. Yu. Fedorova A. Kh. Nurgalieva M. Darvish D. D. Sakaeva E. K. Khusnutdinova D. S. Prokofyeva Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan Сибирский онкологический журнал ovarian cancer molecular genetic research associative analysis genetic polymorphisms hif 1a vegf |
| title | Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan |
| title_full | Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan |
| title_fullStr | Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan |
| title_full_unstemmed | Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan |
| title_short | Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan |
| title_sort | study of the association between i hif1a i and i vegfa i gene polymorphisms and ovarian cancer risk in women from bashkortostan |
| topic | ovarian cancer molecular genetic research associative analysis genetic polymorphisms hif 1a vegf |
| url | https://www.siboncoj.ru/jour/article/view/3465 |
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