Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan

Study of the association between <i>HIF1A</i> and <i>VEGFA</i> gene polymorphisms and ovarian cancer risk in women from Bashkortostan

Background. The major candidate genes for ovarian cancer (BRCA1/2) explain no more than 15–20 % of cases; therefore it is important to focus on the search for new molecular genetic markers. The aim of the study was to analyze the association of rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA...

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Main Authors: E. A. Andreeva, E. T. Aminova, R. R. Faiskhanova, I. R. Zagitov, Y. V. Valova, Yu. Yu. Fedorova, A. Kh. Nurgalieva, M. Darvish, D. D. Sakaeva, E. K. Khusnutdinova, D. S. Prokofyeva
Format: Article
Language:Russian
Published: Russian Academy of Sciences, Tomsk National Research Medical Center 2025-03-01
Series:Сибирский онкологический журнал
Subjects:
ovarian cancer
molecular genetic research
associative analysis
genetic polymorphisms
hif 1a
vegf
Online Access:https://www.siboncoj.ru/jour/article/view/3465
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Summary:Background. The major candidate genes for ovarian cancer (BRCA1/2) explain no more than 15–20 % of cases; therefore it is important to focus on the search for new molecular genetic markers. The aim of the study was to analyze the association of rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA polymorphic variants with the risk of developing ovarian cancer in women from the Republic of Bashkortostan. Material and methods. Our research included DNA samples of women with ovarian cancer (n=205) and women without cancer at the time of blood sampling (n=259) from the Republic of Bashkortostan. Genotyping was carried out using the Real Time PCR method based on TaqMan technology. Results. Polymorphic variants, such as rs11549465/HIF1A, rs3025039/VEGFA, and rs2146323/VEGFA were not associated with the risk of developing ovarian cancer in women of the Republic of Bashkortostan. However, the rs11549465/HIF1A polymorphic locus was significantly correlated with the grade of tumor cell differentiation, and the rs3025039/VEGFA was associated with lymph node metastasis. Conclusion. These polymorphic variants may be associated with ovarian cancer prognosis. to confirm this association, it is necessary to conduct research on a large sample size.
ISSN:1814-4861
2312-3168

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