Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

Epistasis at the SARS-CoV-2 Receptor-Binding Domain Interface and the Propitiously Boring Implications for Vaccine Escape

ABSTRACT At the time of this writing, December 2021, potential emergence of vaccine escape variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a grave global concern. The interface between the receptor-binding domain (RBD) of SARS-CoV-2 spike (S) protein and the host receptor...

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Bibliographic Details
Main Authors: Nash D. Rochman, Guilhem Faure, Yuri I. Wolf, Lydia Freddolino, Feng Zhang, Eugene V. Koonin
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
SARS-CoV-2
Delta variant
Gamma variant
Omicron variant
escape mutants
epistasis
Online Access:https://journals.asm.org/doi/10.1128/mbio.00135-22
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