Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD
Abstract INTRODUCTION Elevated cardiovascular rate pressure product (RPP) has been shown to predict cardiovascular mortality and is associated with poor cognitive test performance among older adults. However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegene...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
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| Online Access: | https://doi.org/10.1002/dad2.70086 |
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| author | Chinenye C. Odo Joe Strong Sarah R. Lose Yue Ma Catherine L. Gallagher Barbara B. Bendlin Henrik Zetterberg Kaj Blennow Cynthia M. Carlsson Gwendlyn Kollmorgen Clara Quijano‐Rubio Nathaniel A. Chin Sanjay Asthana Sterling C. Johnson Jacqueline Pontes Monteiro Ozioma C. Okonkwo |
| author_facet | Chinenye C. Odo Joe Strong Sarah R. Lose Yue Ma Catherine L. Gallagher Barbara B. Bendlin Henrik Zetterberg Kaj Blennow Cynthia M. Carlsson Gwendlyn Kollmorgen Clara Quijano‐Rubio Nathaniel A. Chin Sanjay Asthana Sterling C. Johnson Jacqueline Pontes Monteiro Ozioma C. Okonkwo |
| author_sort | Chinenye C. Odo |
| collection | DOAJ |
| description | Abstract INTRODUCTION Elevated cardiovascular rate pressure product (RPP) has been shown to predict cardiovascular mortality and is associated with poor cognitive test performance among older adults. However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegeneration and neuroinflammation. METHODS RPP was cross‐sectionally evaluated as a predictor of CSF biomarker levels in a cohort of 310 cognitively unimpaired late‐middle‐aged adults at risk for Alzheimer's disease. The primary outcomes were CSF levels of α‐Synuclein, glial fibrillary acidic protein, neurofilament light (NfL), soluble triggering receptor expressed in myeloid cells 2, and total tau. Further analyses examined amyloid beta (Aβ)42/Aβ40, phosphorylated tau 181 (pTau181), and pTau181/Aβ4. RESULTS RPP was positively associated with NfL (β = 0.006, R2 = 0.411, p = 0.012, but Bonferroni‐corrected p ≤ 0.006) and not with other CSF biomarkers of neurodegeneration and neuroinflammation investigated in this sample. DISCUSSION A high myocardial oxygen demand at rest may be related to neuronal death and axonal degeneration in cognitively unimpaired late‐middle‐aged adults. Highlights We explored the relationship between RPP and CSF analytes. Higher RPP was associated with higher NfL but not other measured CSF biomarkers. HR was positively associated with NfL, whereas SBP was not. |
| format | Article |
| id | doaj-art-6c99fcca191e4bbdb6da75912d7a6302 |
| institution | Kabale University |
| issn | 2352-8729 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring |
| spelling | doaj-art-6c99fcca191e4bbdb6da75912d7a63022025-08-20T03:42:18ZengWileyAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring2352-87292025-01-01171n/an/a10.1002/dad2.70086Cardiovascular rate pressure product is associated with NfL in older adults at risk for ADChinenye C. Odo0Joe Strong1Sarah R. Lose2Yue Ma3Catherine L. Gallagher4Barbara B. Bendlin5Henrik Zetterberg6Kaj Blennow7Cynthia M. Carlsson8Gwendlyn Kollmorgen9Clara Quijano‐Rubio10Nathaniel A. Chin11Sanjay Asthana12Sterling C. Johnson13Jacqueline Pontes Monteiro14Ozioma C. Okonkwo15Department of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USAGeriatric Research Education and Clinical Center William S. Middleton Memorial Veterans Hospital Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USAWisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health Madison Wisconsin USAClinical Neurochemistry Laboratory Sahlgrenska University Hospital, Sahlgrenska, Mölndal Gothenburg SwedenDepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USARoche Diagnostics GmbH Penzberg GermanyRoche Diagnostics International Ltd Rotkreuz SwitzerlandDepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USADepartment of Medicine University of Wisconsin‐Madison Madison Wisconsin USAAbstract INTRODUCTION Elevated cardiovascular rate pressure product (RPP) has been shown to predict cardiovascular mortality and is associated with poor cognitive test performance among older adults. However, it is unclear how RPP is related to the cerebrospinal fluid (CSF) biomarkers of neurodegeneration and neuroinflammation. METHODS RPP was cross‐sectionally evaluated as a predictor of CSF biomarker levels in a cohort of 310 cognitively unimpaired late‐middle‐aged adults at risk for Alzheimer's disease. The primary outcomes were CSF levels of α‐Synuclein, glial fibrillary acidic protein, neurofilament light (NfL), soluble triggering receptor expressed in myeloid cells 2, and total tau. Further analyses examined amyloid beta (Aβ)42/Aβ40, phosphorylated tau 181 (pTau181), and pTau181/Aβ4. RESULTS RPP was positively associated with NfL (β = 0.006, R2 = 0.411, p = 0.012, but Bonferroni‐corrected p ≤ 0.006) and not with other CSF biomarkers of neurodegeneration and neuroinflammation investigated in this sample. DISCUSSION A high myocardial oxygen demand at rest may be related to neuronal death and axonal degeneration in cognitively unimpaired late‐middle‐aged adults. Highlights We explored the relationship between RPP and CSF analytes. Higher RPP was associated with higher NfL but not other measured CSF biomarkers. HR was positively associated with NfL, whereas SBP was not.https://doi.org/10.1002/dad2.70086CSF biomarkersmyocardial oxygen demandNfLrate pressure productRPP |
| spellingShingle | Chinenye C. Odo Joe Strong Sarah R. Lose Yue Ma Catherine L. Gallagher Barbara B. Bendlin Henrik Zetterberg Kaj Blennow Cynthia M. Carlsson Gwendlyn Kollmorgen Clara Quijano‐Rubio Nathaniel A. Chin Sanjay Asthana Sterling C. Johnson Jacqueline Pontes Monteiro Ozioma C. Okonkwo Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring CSF biomarkers myocardial oxygen demand NfL rate pressure product RPP |
| title | Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD |
| title_full | Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD |
| title_fullStr | Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD |
| title_full_unstemmed | Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD |
| title_short | Cardiovascular rate pressure product is associated with NfL in older adults at risk for AD |
| title_sort | cardiovascular rate pressure product is associated with nfl in older adults at risk for ad |
| topic | CSF biomarkers myocardial oxygen demand NfL rate pressure product RPP |
| url | https://doi.org/10.1002/dad2.70086 |
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