Induced Treg‐Derived Extracellular Vesicles Suppress CD4+ T‐Cell‐Mediated Inflammation and Ameliorate Bone Loss During Periodontitis Partly Through CD73/Adenosine‐Dependent Immunomodulatory Mechanisms

Induced Treg‐Derived Extracellular Vesicles Suppress CD4+ T‐Cell‐Mediated Inflammation and Ameliorate Bone Loss During Periodontitis Partly Through CD73/Adenosine‐Dependent Immunomodulatory Mechanisms

ABSTRACT Regulatory T cell (Treg)‐derived extracellular vesicles (EVs) represent a contact‐independent mechanism by which Tregs suppress dysregulated immune responses. These EVs carry diverse immunomodulatory molecules, including CD73, an ectoenzyme that hydrolyses AMP into adenosine. Adenosine subs...

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Main Authors: Carolina Rojas, Michelle García, Luis González‐Osuna, Mauricio Campos‐Mora, Enrique Ponce deLeón, Alfredo Sierra‐Cristancho, Claudia Terraza, Cristian Cortez, Luis Daniel Sansores‐España, Paola Carvajal, Jordan Bazoer, Qi Peng, Charlotte Lawson, Lesley A. Smyth, Karina Pino‐Lagos, Rolando Vernal
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Extracellular Vesicles
Subjects:
5’‐nucleotidase
adenosine
extracellular vesicles
periodontitis
regulatory T cell
retinoic acid
Online Access:https://doi.org/10.1002/jev2.70118
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