The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review
<p><strong>Background</strong>: Periprosthetic joint infections (PJIs) pose a significant challenge in orthopedic surgery, and emerging evidence suggests that the gut microbiome may play a crucial role in their development and management. Despite the rarity of these infections, the...
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| Format: | Article |
| Language: | English |
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Copernicus Publications
2025-03-01
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| Series: | Journal of Bone and Joint Infection |
| Online Access: | https://jbji.copernicus.org/articles/10/85/2025/jbji-10-85-2025.pdf |
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| author | A. Singlitico D. Grassa R. Kaplan A. Smimmo G. Maccauro R. Vitiello |
| author_facet | A. Singlitico D. Grassa R. Kaplan A. Smimmo G. Maccauro R. Vitiello |
| author_sort | A. Singlitico |
| collection | DOAJ |
| description | <p><strong>Background</strong>: Periprosthetic joint infections (PJIs) pose a significant challenge in orthopedic surgery, and emerging evidence suggests that the gut microbiome may play a crucial role in their development and management. Despite the rarity of these infections, the continuous increase in prosthetic joint arthroplasties has made understanding how to prevent them more pressing. A stronger comprehension of the disruption of the gut microbiome and how this can lead to more of these infections and other pre-surgical risks may be crucial in preventing them. <strong>Objective</strong>: This article aims to provide a stronger understanding of the topic through the analysis of different pieces of already existing literature to help draw new conclusions and raise potential questions that need answering. <strong>Methods</strong>: A comprehensive search strategy without filters was employed, and multiple papers were thoroughly analyzed, understood, and compiled into this paper. <strong>Conclusions</strong>: Despite the limitations of some of the analyzed studies and finite evidence, this paper suggests that there could be a connection between periprosthetic joint infections and a compromised gut microbiome. However, further research is required to draw a definitive conclusion.</p> |
| format | Article |
| id | doaj-art-6c8e3e0f2606456b9f8de6c8ea2eebdc |
| institution | Kabale University |
| issn | 2206-3552 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Copernicus Publications |
| record_format | Article |
| series | Journal of Bone and Joint Infection |
| spelling | doaj-art-6c8e3e0f2606456b9f8de6c8ea2eebdc2025-08-20T03:42:23ZengCopernicus PublicationsJournal of Bone and Joint Infection2206-35522025-03-0110859210.5194/jbji-10-85-2025The hidden connection between gut microbiota and periprosthetic joint infections: a scoping reviewA. Singlitico0D. Grassa1R. Kaplan2A. Smimmo3G. Maccauro4R. Vitiello5Department of Orthopaedics, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Orthopaedics, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Orthopaedics, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Orthopaedic and Traumatology, Aurelia Hospital Garofalo Healthcare, 00165 Rome, ItalyDepartment of Orthopaedics, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Rome, ItalyDepartment of Orthopaedics, Fondazione Policlinico Universitario Agostino Gemelli IRCSS, Università Cattolica del Sacro Cuore, 00168 Rome, Italy<p><strong>Background</strong>: Periprosthetic joint infections (PJIs) pose a significant challenge in orthopedic surgery, and emerging evidence suggests that the gut microbiome may play a crucial role in their development and management. Despite the rarity of these infections, the continuous increase in prosthetic joint arthroplasties has made understanding how to prevent them more pressing. A stronger comprehension of the disruption of the gut microbiome and how this can lead to more of these infections and other pre-surgical risks may be crucial in preventing them. <strong>Objective</strong>: This article aims to provide a stronger understanding of the topic through the analysis of different pieces of already existing literature to help draw new conclusions and raise potential questions that need answering. <strong>Methods</strong>: A comprehensive search strategy without filters was employed, and multiple papers were thoroughly analyzed, understood, and compiled into this paper. <strong>Conclusions</strong>: Despite the limitations of some of the analyzed studies and finite evidence, this paper suggests that there could be a connection between periprosthetic joint infections and a compromised gut microbiome. However, further research is required to draw a definitive conclusion.</p>https://jbji.copernicus.org/articles/10/85/2025/jbji-10-85-2025.pdf |
| spellingShingle | A. Singlitico D. Grassa R. Kaplan A. Smimmo G. Maccauro R. Vitiello The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review Journal of Bone and Joint Infection |
| title | The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review |
| title_full | The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review |
| title_fullStr | The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review |
| title_full_unstemmed | The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review |
| title_short | The hidden connection between gut microbiota and periprosthetic joint infections: a scoping review |
| title_sort | hidden connection between gut microbiota and periprosthetic joint infections a scoping review |
| url | https://jbji.copernicus.org/articles/10/85/2025/jbji-10-85-2025.pdf |
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