Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area
Introduction: Streptococcus suis (S. suis) disease is a zoonotic infection caused by invasive S. suis and can lead to meningitis, septic shock, arthritis, and endocarditis. Early treatment is the key to reducing mortality. However, clinical manifestations of most cases are atypical, severely limiti...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
The Journal of Infection in Developing Countries
2024-04-01
|
| Series: | Journal of Infection in Developing Countries |
| Subjects: | |
| Online Access: | https://jidc.org/index.php/journal/article/view/18805 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850034362622410752 |
|---|---|
| author | Youwen Ye Huajie Gu Tianyu Li Xiaoyong Dai Bin Shi |
| author_facet | Youwen Ye Huajie Gu Tianyu Li Xiaoyong Dai Bin Shi |
| author_sort | Youwen Ye |
| collection | DOAJ |
| description |
Introduction: Streptococcus suis (S. suis) disease is a zoonotic infection caused by invasive S. suis and can lead to meningitis, septic shock, arthritis, and endocarditis. Early treatment is the key to reducing mortality. However, clinical manifestations of most cases are atypical, severely limiting rapid diagnosis and treatment.
Case report: Here, we report a 74-year-old female patient diagnosed with S. suis infection. The main symptoms were hearing loss, lumbago, and scattered ecchymosis of the lower extremities and trunk. Blood non-specific infection indexes were significantly increased and platelets were significantly decreased; however, no pathogens were obtained from routine blood culture. Finally, the S. suis infection was confirmed by metagenomic next-generation sequencing (mNGS) of blood and cerebrospinal fluid. After antibiotic treatment, the limb and trunk scattered ecchymosis and lumbago symptoms were significantly relieved, but the hearing did not recover.
Conclusions: Human infection with S. suis is rare in central cities, and it is easy to misdiagnose, especially in cases with atypical early symptoms. mNGS technology, combined with clinical observation, is helpful to clarify the direction of diagnosis and treatment, which is conducive to patient recovery.
|
| format | Article |
| id | doaj-art-6c8d8d025d824f5a9ecb83379ac7a338 |
| institution | DOAJ |
| issn | 1972-2680 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-6c8d8d025d824f5a9ecb83379ac7a3382025-08-20T02:57:52ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802024-04-01180410.3855/jidc.18805Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban areaYouwen Ye0Huajie Gu1Tianyu Li2Xiaoyong Dai3Bin Shi4Department of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaGenoxor Medical Science and Technology Inc., Shanghai, ChinaDepartment of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, ChinaDepartment of Emergency Intensive Care Unit, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China Introduction: Streptococcus suis (S. suis) disease is a zoonotic infection caused by invasive S. suis and can lead to meningitis, septic shock, arthritis, and endocarditis. Early treatment is the key to reducing mortality. However, clinical manifestations of most cases are atypical, severely limiting rapid diagnosis and treatment. Case report: Here, we report a 74-year-old female patient diagnosed with S. suis infection. The main symptoms were hearing loss, lumbago, and scattered ecchymosis of the lower extremities and trunk. Blood non-specific infection indexes were significantly increased and platelets were significantly decreased; however, no pathogens were obtained from routine blood culture. Finally, the S. suis infection was confirmed by metagenomic next-generation sequencing (mNGS) of blood and cerebrospinal fluid. After antibiotic treatment, the limb and trunk scattered ecchymosis and lumbago symptoms were significantly relieved, but the hearing did not recover. Conclusions: Human infection with S. suis is rare in central cities, and it is easy to misdiagnose, especially in cases with atypical early symptoms. mNGS technology, combined with clinical observation, is helpful to clarify the direction of diagnosis and treatment, which is conducive to patient recovery. https://jidc.org/index.php/journal/article/view/18805Streptococcus suiszoonosismeningitismetagenomemNGS |
| spellingShingle | Youwen Ye Huajie Gu Tianyu Li Xiaoyong Dai Bin Shi Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area Journal of Infection in Developing Countries Streptococcus suis zoonosis meningitis metagenome mNGS |
| title | Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area |
| title_full | Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area |
| title_fullStr | Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area |
| title_full_unstemmed | Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area |
| title_short | Metagenomic next-generation sequencing confirmed a case of sporadic human infection with Streptococcus suis in an urban area |
| title_sort | metagenomic next generation sequencing confirmed a case of sporadic human infection with streptococcus suis in an urban area |
| topic | Streptococcus suis zoonosis meningitis metagenome mNGS |
| url | https://jidc.org/index.php/journal/article/view/18805 |
| work_keys_str_mv | AT youwenye metagenomicnextgenerationsequencingconfirmedacaseofsporadichumaninfectionwithstreptococcussuisinanurbanarea AT huajiegu metagenomicnextgenerationsequencingconfirmedacaseofsporadichumaninfectionwithstreptococcussuisinanurbanarea AT tianyuli metagenomicnextgenerationsequencingconfirmedacaseofsporadichumaninfectionwithstreptococcussuisinanurbanarea AT xiaoyongdai metagenomicnextgenerationsequencingconfirmedacaseofsporadichumaninfectionwithstreptococcussuisinanurbanarea AT binshi metagenomicnextgenerationsequencingconfirmedacaseofsporadichumaninfectionwithstreptococcussuisinanurbanarea |