Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized rats
Objective: Natural compounds derived from plants have demonstrated therapeutic effects in various liver-related disorders. This study explored the impact of Baccaurea ramiflora fruit peel powder on oxidative stress and fibrosis in hepatic damage induced by carbon tetrachloride (CCl4) in ovariectomiz...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Phytomedicine Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667031324001933 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861106383257600 |
|---|---|
| author | Tahsin Zahan Mirza Alimullah Ishrat Jahan Md. Borhan Uddin Khondker Ayesha Akter Md. Junaeid Rahman Shahnaz Siddiqua Kamrun Nahar Ela Sakil Amin Khondoker Shahin Ahmed Hemayet Hossain Ferdous Khan Md Ashraful Alam Nusrat Subhan |
| author_facet | Tahsin Zahan Mirza Alimullah Ishrat Jahan Md. Borhan Uddin Khondker Ayesha Akter Md. Junaeid Rahman Shahnaz Siddiqua Kamrun Nahar Ela Sakil Amin Khondoker Shahin Ahmed Hemayet Hossain Ferdous Khan Md Ashraful Alam Nusrat Subhan |
| author_sort | Tahsin Zahan |
| collection | DOAJ |
| description | Objective: Natural compounds derived from plants have demonstrated therapeutic effects in various liver-related disorders. This study explored the impact of Baccaurea ramiflora fruit peel powder on oxidative stress and fibrosis in hepatic damage induced by carbon tetrachloride (CCl4) in ovariectomized rats. Methods: High-performance liquid chromatography (HPLC) analysis was done on Baccaurea ramiflora fruit peel powder extract to confirm the presence of phenolic antioxidants. Female Long Evans ovariectomized rats, weighing between 220 and 260 gs, were allocated into five groups. All of the rats were sacrificed at the end of the study to examine the physiological parameters and oxidative stress markers, and tissue samples were obtained. In addition, the process of histological staining of liver sections was done for inflammation as well as tissue fibrosis. Results: The HPLC study of Baccaurea ramiflora fruit peel powder extract revealed the presence of gallic acid, caffeic acid, trans-ferulic acid, rutin hydrate, and rosmarinic acid. Administration of CCl4 in rats resulted in elevated plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities. Supplementing rats with Baccaurea ramiflora fruit peel powder in CCl4 administered rats significantly decreased the transaminase activities in plasma. CCl4 administration in rats resulted in an elevation of oxidative stress and lipid peroxidation. The oxidative stress markers including malondialdehyde (MDA), nitric oxide (NO), and advanced oxidation protein product (AOPP) were significantly reduced by Baccaurea ramiflora fruit peel powder supplementation in CCl4-administered rats. The catalase and superoxide dismutase activities were also restored in the plasma of CCl4-administered rats. The results are comparable to the effects of silymarin therapy in rats that were administered CCl4. Baccaurea ramiflora fruit peel powder also modulated the oxidative stress genes and suppressed the inflammatory genes in the liver of CCl4-administered rats. Conclusion: These findings indicate that Baccaurea ramiflora fruit peel powder supplementation can offer protective effects against liver damage induced by CCl4. This protection is achieved by mitigating lipid peroxidation, reducing oxidative stress and inflammation, alleviating fibrosis, and enhancing the cellular antioxidant system. |
| format | Article |
| id | doaj-art-6c8a0354ae55439cb3c9d672af9f97f0 |
| institution | Kabale University |
| issn | 2667-0313 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Phytomedicine Plus |
| spelling | doaj-art-6c8a0354ae55439cb3c9d672af9f97f02025-02-10T04:35:17ZengElsevierPhytomedicine Plus2667-03132025-02-0151100719Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized ratsTahsin Zahan0Mirza Alimullah1Ishrat Jahan2Md. Borhan Uddin3Khondker Ayesha Akter4Md. Junaeid Rahman5Shahnaz Siddiqua6Kamrun Nahar Ela7Sakil Amin8Khondoker Shahin Ahmed9Hemayet Hossain10Ferdous Khan11Md Ashraful Alam12Nusrat Subhan13Department of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmacy, East West University, Dhaka, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmacy, University of Developmental Alternative, BangladeshBCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka-1205, BangladeshBCSIR Laboratories, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka-1205, BangladeshDepartment of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, Bangladesh; Corresponding authors at: Department of Pharmaceutical Sciences, North South University, BangladeshDepartment of Pharmaceutical Sciences, North South University, Bangladesh; Corresponding authors at: Department of Pharmaceutical Sciences, North South University, BangladeshObjective: Natural compounds derived from plants have demonstrated therapeutic effects in various liver-related disorders. This study explored the impact of Baccaurea ramiflora fruit peel powder on oxidative stress and fibrosis in hepatic damage induced by carbon tetrachloride (CCl4) in ovariectomized rats. Methods: High-performance liquid chromatography (HPLC) analysis was done on Baccaurea ramiflora fruit peel powder extract to confirm the presence of phenolic antioxidants. Female Long Evans ovariectomized rats, weighing between 220 and 260 gs, were allocated into five groups. All of the rats were sacrificed at the end of the study to examine the physiological parameters and oxidative stress markers, and tissue samples were obtained. In addition, the process of histological staining of liver sections was done for inflammation as well as tissue fibrosis. Results: The HPLC study of Baccaurea ramiflora fruit peel powder extract revealed the presence of gallic acid, caffeic acid, trans-ferulic acid, rutin hydrate, and rosmarinic acid. Administration of CCl4 in rats resulted in elevated plasma levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) activities. Supplementing rats with Baccaurea ramiflora fruit peel powder in CCl4 administered rats significantly decreased the transaminase activities in plasma. CCl4 administration in rats resulted in an elevation of oxidative stress and lipid peroxidation. The oxidative stress markers including malondialdehyde (MDA), nitric oxide (NO), and advanced oxidation protein product (AOPP) were significantly reduced by Baccaurea ramiflora fruit peel powder supplementation in CCl4-administered rats. The catalase and superoxide dismutase activities were also restored in the plasma of CCl4-administered rats. The results are comparable to the effects of silymarin therapy in rats that were administered CCl4. Baccaurea ramiflora fruit peel powder also modulated the oxidative stress genes and suppressed the inflammatory genes in the liver of CCl4-administered rats. Conclusion: These findings indicate that Baccaurea ramiflora fruit peel powder supplementation can offer protective effects against liver damage induced by CCl4. This protection is achieved by mitigating lipid peroxidation, reducing oxidative stress and inflammation, alleviating fibrosis, and enhancing the cellular antioxidant system.http://www.sciencedirect.com/science/article/pii/S2667031324001933Baccaurea ramifloraFibrosisInflammationLipid peroxidationOxidative stress |
| spellingShingle | Tahsin Zahan Mirza Alimullah Ishrat Jahan Md. Borhan Uddin Khondker Ayesha Akter Md. Junaeid Rahman Shahnaz Siddiqua Kamrun Nahar Ela Sakil Amin Khondoker Shahin Ahmed Hemayet Hossain Ferdous Khan Md Ashraful Alam Nusrat Subhan Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized rats Phytomedicine Plus Baccaurea ramiflora Fibrosis Inflammation Lipid peroxidation Oxidative stress |
| title | Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized rats |
| title_full | Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized rats |
| title_fullStr | Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized rats |
| title_full_unstemmed | Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized rats |
| title_short | Baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration, oxidative stress, and fibrosis in carbon tetrachloride (CCl4) administered ovariectomized rats |
| title_sort | baccaurea ramiflora fruit peel powder supplementation prevented inflammatory cell infiltration oxidative stress and fibrosis in carbon tetrachloride ccl4 administered ovariectomized rats |
| topic | Baccaurea ramiflora Fibrosis Inflammation Lipid peroxidation Oxidative stress |
| url | http://www.sciencedirect.com/science/article/pii/S2667031324001933 |
| work_keys_str_mv | AT tahsinzahan baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT mirzaalimullah baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT ishratjahan baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT mdborhanuddin baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT khondkerayeshaakter baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT mdjunaeidrahman baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT shahnazsiddiqua baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT kamrunnaharela baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT sakilamin baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT khondokershahinahmed baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT hemayethossain baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT ferdouskhan baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT mdashrafulalam baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats AT nusratsubhan baccaurearamiflorafruitpeelpowdersupplementationpreventedinflammatorycellinfiltrationoxidativestressandfibrosisincarbontetrachlorideccl4administeredovariectomizedrats |