Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study.
<h4>Background</h4>Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune sys...
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Public Library of Science (PLoS)
2024-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0302464&type=printable |
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| author | Lyle G Best Esther Erdei Karin Haack Jack W Kent Kimberly M Malloy Deborah E Newman Marcia O'Leary Rae A O'Leary Quan Sun Ana Navas-Acien Nora Franceschini Shelley A Cole |
| author_facet | Lyle G Best Esther Erdei Karin Haack Jack W Kent Kimberly M Malloy Deborah E Newman Marcia O'Leary Rae A O'Leary Quan Sun Ana Navas-Acien Nora Franceschini Shelley A Cole |
| author_sort | Lyle G Best |
| collection | DOAJ |
| description | <h4>Background</h4>Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205.<h4>Methodology/principal findings</h4>The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2/1/20 through 3/1/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway, APOE, TMPRSS2, TLR3, the HLA complex and the ABO blood group, only rs1205, a 3' untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001-3.453, p = 0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness.<h4>Conclusion</h4>A T-dominant genotype of rs1205 in the CRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted. |
| format | Article |
| id | doaj-art-6c86799c781a45b882ce99eb11821661 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-6c86799c781a45b882ce99eb118216612025-08-20T03:51:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-01194e030246410.1371/journal.pone.0302464Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study.Lyle G BestEsther ErdeiKarin HaackJack W KentKimberly M MalloyDeborah E NewmanMarcia O'LearyRae A O'LearyQuan SunAna Navas-AcienNora FranceschiniShelley A Cole<h4>Background</h4>Although COVID-19 infection has been associated with a number of clinical and environmental risk factors, host genetic variation has also been associated with the incidence and morbidity of infection. The CRP gene codes for a critical component of the innate immune system and CRP variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205.<h4>Methodology/principal findings</h4>The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2/1/20 through 3/1/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway, APOE, TMPRSS2, TLR3, the HLA complex and the ABO blood group, only rs1205, a 3' untranslated region variant in the CRP gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001-3.453, p = 0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness.<h4>Conclusion</h4>A T-dominant genotype of rs1205 in the CRP gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0302464&type=printable |
| spellingShingle | Lyle G Best Esther Erdei Karin Haack Jack W Kent Kimberly M Malloy Deborah E Newman Marcia O'Leary Rae A O'Leary Quan Sun Ana Navas-Acien Nora Franceschini Shelley A Cole Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study. PLoS ONE |
| title | Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study. |
| title_full | Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study. |
| title_fullStr | Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study. |
| title_full_unstemmed | Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study. |
| title_short | Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study. |
| title_sort | genetic variant rs1205 is associated with covid 19 outcomes the strong heart study and strong heart family study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0302464&type=printable |
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