Arcyriaflavin A, a cyclin D1/CDK4 inhibitor, suppresses tumor growth, migration, and invasion of metastatic melanoma cells

Arcyriaflavin A, a cyclin D1/CDK4 inhibitor, suppresses tumor growth, migration, and invasion of metastatic melanoma cells

Abstract Background Despite advancements in targeted therapy and immunotherapy, cutaneous melanoma continues to have a high mortality rate and poor prognosis, with therapies having limited efficacy in advanced melanoma. Therefore, it is crucial to develop novel therapeutics with proven clinical pote...

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Bibliographic Details
Main Authors: Dokyeong Kim, Junseong Park, Yoon-Seob Kim, Okcho Na, Minyoung Park, Songzi Zhang, Sumin Cho, Yeun-Jun Chung
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cancer Cell International
Subjects:
Anti-cancer therapy
Arcyriaflavin A
Cyclin D1
CDK4
Metastatic melanoma
Online Access:https://doi.org/10.1186/s12935-025-03675-4
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