OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIAL
Aim of the study Using efficient addition techniques and biomaterials is essential to ensure the success of implant treatment. The study aimed to evaluate the degree of bone formation of two bone augmentation biomaterials compared to natural healing using optical coherence tomography. Materials and...
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Romanian Society of Oral Rehabilitation
2025-06-01
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| Series: | Romanian Journal of Oral Rehabilitation |
| Online Access: | https://rjor.ro/optical-coherence-tomography-qualitative-analysis-of-bone-regeneration-in-rats-with-titanium-reinforced-hydroxyapatite-biomaterial-and-porcine-bone-derived-grafting-material/ |
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| author | Antonia Samia Khaddour Alin Gabriel Ionescu Emma Cristina Draghici Răzvan Eugen Ghiţă Razvan Mercut Horia Octavian Manolea Eugen Osiac Oana Gingu Adrian Camen Sanda Mihaela Popescu |
| author_facet | Antonia Samia Khaddour Alin Gabriel Ionescu Emma Cristina Draghici Răzvan Eugen Ghiţă Razvan Mercut Horia Octavian Manolea Eugen Osiac Oana Gingu Adrian Camen Sanda Mihaela Popescu |
| author_sort | Antonia Samia Khaddour |
| collection | DOAJ |
| description | Aim of the study Using efficient addition techniques and biomaterials is essential to ensure the success of implant treatment. The study aimed to evaluate the degree of bone formation of two bone augmentation biomaterials compared to natural healing using optical coherence tomography. Materials and methods Three study groups were made of Wistar rats, and cavities with a diameter of 3 mm were made in the parietal bone. The three groups were divided: A, a negative control group; B, a positive control group, in which a commercial porcine grafting material was used; and C, a study group, in which an experimental synthetic grafting material was used. Samples were collected at 8 and 16 weeks. The images obtained from analysing the samples using optical coherence tomography were analysed with Image J software. Results The results provided information related to the healing pattern of the created cavities and the degree of their filling with newly formed bone tissue. Statistically significant differences were recorded in bone density at the grafted bone defect level between the two biomaterials, compared to the control group, and between the two evaluation stages, at 8 and 16 weeks. The highest integrated bone density was recorded for the synthetic material based on hydroxyapatite reinforced with titanium particles, followed by the porcine xenograft. Conclusions OCT examination is a valuable tool for evaluating the osseointegration of bone grafts since their higher refractive index allows for better identification of bone regeneration patterns.
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| format | Article |
| id | doaj-art-6c8383cdceab44bf898f836f1cd0aebd |
| institution | Kabale University |
| issn | 2066-7000 2601-4661 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Romanian Society of Oral Rehabilitation |
| record_format | Article |
| series | Romanian Journal of Oral Rehabilitation |
| spelling | doaj-art-6c8383cdceab44bf898f836f1cd0aebd2025-08-21T07:55:22ZengRomanian Society of Oral RehabilitationRomanian Journal of Oral Rehabilitation2066-70002601-46612025-06-0117290592610.62610/RJOR.2025.2.17.83OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIALAntonia Samia Khaddour0Alin Gabriel Ionescu1Emma Cristina Draghici2Răzvan Eugen Ghiţă3Razvan Mercut4Horia Octavian Manolea5Eugen Osiac6Oana Gingu7Adrian Camen8Sanda Mihaela Popescu9University of Medicine and Pharmacy of Craiova, Romania, Faculty of Dentistry, Department of Oral RehabilitationUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Medicine, Department of History of MedicineUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dentistry, Department of Oral RehabilitationUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dentistry, Department of Oral RehabilitationUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Medicine, Department of Plastic and Reconstructive SurgeryUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dentistry, Department of Dental MaterialsUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Medicine, Department of BiophysicsUniversity of Craiova, Romania, Faculty of Mechanics, Department of Automotive, Transports and Industrial EngineeringUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dentistry, Department of Oral and Maxillofacial SurgeryUniversity of Medicine and Pharmacy of Craiova, Romania, Faculty of Dentistry, Department of Oral RehabilitationAim of the study Using efficient addition techniques and biomaterials is essential to ensure the success of implant treatment. The study aimed to evaluate the degree of bone formation of two bone augmentation biomaterials compared to natural healing using optical coherence tomography. Materials and methods Three study groups were made of Wistar rats, and cavities with a diameter of 3 mm were made in the parietal bone. The three groups were divided: A, a negative control group; B, a positive control group, in which a commercial porcine grafting material was used; and C, a study group, in which an experimental synthetic grafting material was used. Samples were collected at 8 and 16 weeks. The images obtained from analysing the samples using optical coherence tomography were analysed with Image J software. Results The results provided information related to the healing pattern of the created cavities and the degree of their filling with newly formed bone tissue. Statistically significant differences were recorded in bone density at the grafted bone defect level between the two biomaterials, compared to the control group, and between the two evaluation stages, at 8 and 16 weeks. The highest integrated bone density was recorded for the synthetic material based on hydroxyapatite reinforced with titanium particles, followed by the porcine xenograft. Conclusions OCT examination is a valuable tool for evaluating the osseointegration of bone grafts since their higher refractive index allows for better identification of bone regeneration patterns. https://rjor.ro/optical-coherence-tomography-qualitative-analysis-of-bone-regeneration-in-rats-with-titanium-reinforced-hydroxyapatite-biomaterial-and-porcine-bone-derived-grafting-material/ |
| spellingShingle | Antonia Samia Khaddour Alin Gabriel Ionescu Emma Cristina Draghici Răzvan Eugen Ghiţă Razvan Mercut Horia Octavian Manolea Eugen Osiac Oana Gingu Adrian Camen Sanda Mihaela Popescu OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIAL Romanian Journal of Oral Rehabilitation |
| title | OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIAL |
| title_full | OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIAL |
| title_fullStr | OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIAL |
| title_full_unstemmed | OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIAL |
| title_short | OPTICAL COHERENCE TOMOGRAPHY QUALITATIVE ANALYSIS OF BONE REGENERATION IN RATS WITH TITANIUM REINFORCED HYDROXYAPATITE BIOMATERIAL AND PORCINE BONE-DERIVED GRAFTING MATERIAL |
| title_sort | optical coherence tomography qualitative analysis of bone regeneration in rats with titanium reinforced hydroxyapatite biomaterial and porcine bone derived grafting material |
| url | https://rjor.ro/optical-coherence-tomography-qualitative-analysis-of-bone-regeneration-in-rats-with-titanium-reinforced-hydroxyapatite-biomaterial-and-porcine-bone-derived-grafting-material/ |
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