Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice
Aim of investigation. To study polymorphism of СYP2E1-1293 G/C (c1/c2), CYP 3А4 1А/1В, NAT2 Leu161Leu (481 c/t), GSTP1 Ile105Val, IL4 C-589T, TNF-α G-308A genes at syndrome of obstructive jaundice and uncomplicated gallstone disease.Material and methods. Overall 54 patients were divided into three c...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2015-09-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/1029 |
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| author | A. A. Natalsky S. V. Tarasenko A. A. Nikiforov O. V. Zaytsev O. D. Peskov |
| author_facet | A. A. Natalsky S. V. Tarasenko A. A. Nikiforov O. V. Zaytsev O. D. Peskov |
| author_sort | A. A. Natalsky |
| collection | DOAJ |
| description | Aim of investigation. To study polymorphism of СYP2E1-1293 G/C (c1/c2), CYP 3А4 1А/1В, NAT2 Leu161Leu (481 c/t), GSTP1 Ile105Val, IL4 C-589T, TNF-α G-308A genes at syndrome of obstructive jaundice and uncomplicated gallstone disease.Material and methods. Overall 54 patients were divided into three comparison groups: those with obstructive jaundice of benign etiology, with cholestasis due to malignancy and uncomplicated gallstone disease. Genomic DNA of patients obtained from blood leukocytes analysed with application of «DNK-ekspresskrov» reagent utilizing «SNP-ekspress-RV» device of LLC Research and production company «Litekh» (Moscow).Results. Carriage of C allele of СYP2E1 gene is a risk factor of development of biliary diseases. The interrelation of A allele of TNF-α gene G-308A (OR=2,68, 95% CI 1,23-5,84) with high risk of obstructive jaundice due to choledocholithiasis was revealed. At the same time carriage of Т-allele of NAT2 Leu161Leu and IL4 C-589T genes reduces risk of obstructive jaundice of benign etiology.Conclusion. The high risk of biliary diseases is associated to allele C of СYP2E1-1293 G/C gene. Carriers of A allele of TNF-α gene G-308A have higher risk of obstructive jaundice on a background of gallstone disease, while Т alleles of NAT2 Leu161Leu and IL4 C-589T genes have protective action for posthepatic cholestasis. |
| format | Article |
| id | doaj-art-6c7da9c65c1346bea019d8d526ff3b55 |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2015-09-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-6c7da9c65c1346bea019d8d526ff3b552025-02-10T16:14:34ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732015-09-012542328634Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundiceA. A. Natalsky0S. V. Tarasenko1A. A. Nikiforov2O. V. Zaytsev3O. D. Peskov4Pavlov Ryazan State Medical University, Ministry of heathcare of the Russian FederationPavlov Ryazan State Medical University, Ministry of heathcare of the Russian FederationPavlov Ryazan State Medical University, Ministry of heathcare of the Russian FederationPavlov Ryazan State Medical University, Ministry of heathcare of the Russian FederationPavlov Ryazan State Medical University, Ministry of heathcare of the Russian FederationAim of investigation. To study polymorphism of СYP2E1-1293 G/C (c1/c2), CYP 3А4 1А/1В, NAT2 Leu161Leu (481 c/t), GSTP1 Ile105Val, IL4 C-589T, TNF-α G-308A genes at syndrome of obstructive jaundice and uncomplicated gallstone disease.Material and methods. Overall 54 patients were divided into three comparison groups: those with obstructive jaundice of benign etiology, with cholestasis due to malignancy and uncomplicated gallstone disease. Genomic DNA of patients obtained from blood leukocytes analysed with application of «DNK-ekspresskrov» reagent utilizing «SNP-ekspress-RV» device of LLC Research and production company «Litekh» (Moscow).Results. Carriage of C allele of СYP2E1 gene is a risk factor of development of biliary diseases. The interrelation of A allele of TNF-α gene G-308A (OR=2,68, 95% CI 1,23-5,84) with high risk of obstructive jaundice due to choledocholithiasis was revealed. At the same time carriage of Т-allele of NAT2 Leu161Leu and IL4 C-589T genes reduces risk of obstructive jaundice of benign etiology.Conclusion. The high risk of biliary diseases is associated to allele C of СYP2E1-1293 G/C gene. Carriers of A allele of TNF-α gene G-308A have higher risk of obstructive jaundice on a background of gallstone disease, while Т alleles of NAT2 Leu161Leu and IL4 C-589T genes have protective action for posthepatic cholestasis.https://www.gastro-j.ru/jour/article/view/1029polymorphism of genesinterleukinsobstructive jaundice |
| spellingShingle | A. A. Natalsky S. V. Tarasenko A. A. Nikiforov O. V. Zaytsev O. D. Peskov Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice Российский журнал гастроэнтерологии, гепатологии, колопроктологии polymorphism of genes interleukins obstructive jaundice |
| title | Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice |
| title_full | Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice |
| title_fullStr | Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice |
| title_full_unstemmed | Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice |
| title_short | Genetic polymorphism of xenobiotic biotransformation genes, TNF-α and IL-4 in obstructive jaundice |
| title_sort | genetic polymorphism of xenobiotic biotransformation genes tnf α and il 4 in obstructive jaundice |
| topic | polymorphism of genes interleukins obstructive jaundice |
| url | https://www.gastro-j.ru/jour/article/view/1029 |
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