Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer

Hypoxia-driven mobilization of altruistic cancer stem cells in platinum-treated head and neck cancer

BackgroundHead and neck cancers harbor dormant cancer stem cells (CSCs). This study explores how platinum therapy impacts these cells in a non-genetic manner and the role of hypoxia in this process. Previously, we identified a novel population of CSCs exhibiting an “altruistic” phenotype, sacrificin...

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Main Authors: Lekhika Pathak, Bidisha Pal, Joyeeta Talukdar, Partha Jyoti Saikia, Sorra Sandhya, Wale Tasabehji, Hong Li, Jyotirmoy Phukan, Anjan Bhuyan, Sanjukta Patra, Bikul Das
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
circulating tumor cells
head and neck squamous cell carcinoma (HNSCC)
tumor stemness defense (TSD)
cancer stem cells (CSCs)
tumor hypoxia
platinum chemotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1336882/full
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