Development and Preclinical Testing of a Novel Neurodenervant in the Rat: C3 Transferase Mitigates Botulinum Toxin’s Adverse Effects on Muscle Mechanics

Development and Preclinical Testing of a Novel Neurodenervant in the Rat: C3 Transferase Mitigates Botulinum Toxin’s Adverse Effects on Muscle Mechanics

Spasticity, characterized by elevated muscle tone, is commonly managed with botulinum toxin type A (BTX-A). However, BTX-A can paradoxically increase passive muscle forces, narrow muscles’ length range of force exertion (l<sub>range</sub>), and elevate extracellular matrix (ECM) stiffnes...

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Bibliographic Details
Main Authors: Cemre Su Kaya Keles, Zeynep D. Akdeniz Dogan, Can A. Yucesoy
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Toxins
Subjects:
botulinum toxin type A
C3 transferase
spasticity management
muscle force
range of motion
extracellular matrix stiffness
Online Access:https://www.mdpi.com/2072-6651/17/5/234
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