DRG2 levels in prostate cancer cell lines predict response to PARP inhibitor during docetaxel treatment

DRG2 levels in prostate cancer cell lines predict response to PARP inhibitor during docetaxel treatment

"Purpose: Developmentally regulated GTP-binding protein 2 (DRG2) regulates microtubule dynamics and G2/M arrest during docetaxel treatment. Poly ADP-ribose polymerase (PARP) acts as an important repair system for DNA damage caused by docetaxel treatment. This study investigated whether DRG2 exp...

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Bibliographic Details
Main Authors: Jeong Min Lee, Won Hyeok Lee, Seung Hyeon Cho, Jeong Woo Park, Hyuk Nam Kwon, Ji Hye Kim, Sang Hun Lee, Ji Hyung Yoon, Sungchan Park, Seong Cheol Kim
Format: Article
Language:English
Published: Korean Urological Association 2025-01-01
Series:Investigative and Clinical Urology
Subjects:
docetaxel
parp inhibitor
prostate cancer
Online Access:https://www.icurology.org/pdf/10.4111/icu.20240263
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